CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer

CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical...

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Bibliographic Details
Published inMolecular cancer Vol. 17; no. 1; pp. 137 - 6
Main Authors Tang, Weiwei, Fu, Kai, Sun, Handong, Rong, Dawei, Wang, Hanjin, Cao, Hongyong
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 20.09.2018
BioMed Central
BMC
Subjects
Biomarker
Biomarkers
Biosynthesis
Cancer patients
circRNAs
Data processing
Diagnosis
Disease
Exosomes
Gastric cancer
Gene expression
Genetic aspects
Health aspects
Letter to the Editor
Metastases
Microarray
Multivariate analysis
Plasma
RNA
Statistical analysis
Stomach cancer
Volcanoes
United States > US
China
Plasma
circRNAs
Biomarker
Exosomes
Microarray
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Summary:CircRNA expression profiles for gastric cancer (GC) were screened using plasma samples from 10 GC patients with different TNM stages and 5 healthy individuals as controls. Results showed lower expression of circ-KIAA1244 in GC tissues, plasmas, and cells compare to normal controls. Further clinical data analysis demonstrated that a decreased expression of circ-KIAA1244 in plasmas was negatively correlated with TNM stage and lymphatic metastasis, and a shorter overall survival time of GC patients. Moreover, we found that circ-KIAA1244 could be detected in GC plasma exosomes and showed no obvious significance compared to the expression level in the corresponding plasmas. This study revealed a GC-tissues-derived circ-KIAA1244 could serve a novel circulating biomarker for detection of GC.
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ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-018-0888-8