Effect of Intensive Therapy of Multiple Factors Intervention on Vascular Complications in Type 2 Diabetes

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 23; no. 1; pp. 16 - 18
• Main Author: 吴汉妮 张淑玲 等
• Format: Journal Article
• Language: English
• Published: Department of Endocrinology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 2003
• Subjects: 2型糖尿病; 多因子干预; 强化治疗; 血管性并发症; vascular complications; intensive therapy; type 2 diabetes; multiple factors intervention
• ISSN: 1672-0733; 1993-1352

The effects of intensive versus regular therapy on incidence and progress of microalbumin-uria in type 2 diabetes were compared.During a follow-up of 3 years,96 cases of diabetes mellitus were randomized to intensive and regular therapy groups.HbAic goal was same in the two groups,but the goal of blood pressure(Bp) and lipid was more strict in the intensive therapy group than in the regular therapy group.There was statistically significant difference in the incidence and progres-sion of vascular complications between the two groups.Logistic stepwise-regression analysis (odds ra-tion,OR)showed that there was significant difference in the progression of nephropathy(OR 0.24,95% CI0.12-0.76),retinopathy(OR 0.38,95% CI0.16-0.88),peripheral neuropathy (OR 0.42,95% CI 0.22-0.86)and autonomic neuropathy(OR 0.29,95% CI0.12-0.86)between the two groups(P<0.01).It was concouded that intensive blood glucose controlling could retard dia-betic vascular complications.Intensive therapy of multiple factors interventions(controlling Bp,regu-lating blood lipid,improving microcirculation) could decrease various risk factors for diabetic vascular complications.