Rcorrector: efficient and accurate error correction for Illumina RNA-seq reads

• Published in: Gigascience Vol. 4; no. 1; p. 48
• Main Authors: Song, Li, Florea, Liliana
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 19.10.2015; BioMed Central
• Subjects: Alternative splicing; Bioinformatics; Error analysis; Error correction; Error correction & detection; Gene expression; Gene sequencing; Graph theory; Next-generation sequencing; Ribonucleic acid; RNA; RNA - genetics; Sequence Analysis, RNA - methods; Technical Note; Transcriptomics; Whole genome sequencing; RNA-seq; Next-generation sequencing; Error correction; k-mers

Abstract Background Next-generation sequencing of cellular RNA (RNA-seq) is rapidly becoming the cornerstone of transcriptomic analysis. However, sequencing errors in the already short RNA-seq reads complicate bioinformatics analyses, in particular alignment and assembly. Error correction methods ha...