New Taxane Diterpenoids from the Roots of Taiwanese Taxus mairei

• Published in: Chemical & pharmaceutical bulletin Vol. 50; no. 6; pp. 781 - 787
• Main Authors: Shen, Ya-Ching, Chang, Yao-To, Lin, Yu-Chi, Lin, Chung-Ling, Kuo, Yao-Haur, Chen, Ching-Yeu
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 01.06.2002; Pharmaceutical Soc Japan; Maruzen; Japan Science and Technology Agency
• Subjects: Biological and medical sciences; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - isolation & purification; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Diterpenes - chemistry; Diterpenes - isolation & purification; General pharmacology; Life Sciences & Biomedicine; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Plant Roots - chemistry; Science & Technology; Taiwan; Taxaceae; taxane diterpenoids; Taxoids; taxumairols; Taxus - chemistry; Taxus mairei; Asia; Taiwan; SEEDS; YUNNANENSIS; taxumairols; Taxus mairei; taxane diterpenoids; Taxaceae; BARK; Terpenoid; Root; Taxus; Pharmacognosy; Tetracyclic compound; Tricyclic compound; Oxygen heterocycle; Medicinal plant; Taxane derivatives; Gymnospermae; Plant origin; Diterpene; Isolation; Coniferales; Spermatophyta; Polyol; Acylate; Structural analysis
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.50.781

Five new taxane diterpenoids, taxumairols G (1), H (2), I (3), J (4), and L (5) were isolated from extracts of the roots of Taiwanese Taxus mairei (LEMEE & LEVL.) S. Y. Hu. Compounds 1—4 belong to the new 11(15→1)-abeo-taxene system, having a tetrahydrofuran ring along carbons C-2, C-3, C-4 and C-20. Compounds 3 and 4 contain an isopropenyl group at C-1 while compounds 1 and 2 are attached with a benzoxyl group at C-15. The structures of compounds 1—5 were determined on the basis of two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY) experiments.