The convergent roles of tapasin and HLA-DM in antigen presentation

• Published in: Trends in immunology Vol. 29; no. 3; pp. 141 - 147
• Main Authors: Sadegh-Nasseri, Scheherazade, Chen, Mingnan, Narayan, Kedar, Bouvier, Marlene
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2008; Elsevier Limited
• Subjects: Allergy and Immunology; Animals; Antigen Presentation - immunology; Chemical bonds; HLA-D Antigens - metabolism; HLA-D Antigens - physiology; Humans; Membrane Transport Proteins - metabolism; Membrane Transport Proteins - physiology; Peptides; Proteins; Women

Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous sources that bind to major histocompatibility complex (MHC) class I and class II molecules and are presented on antigen-presenting cells. MHC class I and class II structures and maturation pathways have evolved to...