The convergent roles of tapasin and HLA-DM in antigen presentation
Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous sources that bind to major histocompatibility complex (MHC) class I and class II molecules and are presented on antigen-presenting cells. MHC class I and class II structures and maturation pathways have evolved to...
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Published in | Trends in immunology Vol. 29; no. 3; pp. 141 - 147 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.03.2008
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous sources that bind to major histocompatibility complex (MHC) class I and class II molecules and are presented on antigen-presenting cells. MHC class I and class II structures and maturation pathways have evolved to optimize antigen presentation to their respective T cells. The accessory proteins tapasin and HLA-DM (DM) crucially influence the selection of peptides that bind to the MHC molecules. We discuss here the dynamic interactions of tapasin and DM with their corresponding MHC molecules that indicate striking parallels. Utilization of a common mode of peptide selection by two different, but related, biological systems argue for its mechanistic validity. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 Present address: University of Illinois at Chicago, College of Medicine, Department of Microbiology and Immunology, 835 South Wolcott (MC 790), Chicago, IL 60612, USA These authors contributed equally to this work. |
ISSN: | 1471-4906 1471-4981 |
DOI: | 10.1016/j.it.2008.01.001 |