Hypothalamic–pituitary–adrenal axis response to acute psychosocial stress: Effects of biological sex and circulating sex hormones

Highlights • Healthy young men and women (in the follicular phase of the menstrual cycle) completed the Trier Social Stress Test. • Post-stress hypothalamic–pituitary–adrenal (HPA) axis hormone responses were greater in men than women. • Pre-stress testosterone levels were negatively associated with...

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Published inPsychoneuroendocrinology Vol. 66; pp. 47 - 55
Main Authors Stephens, Mary Ann C, Mahon, Pamela B, McCaul, Mary E, Wand, Gary S
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2016
Subjects
Adolescent
Adrenocorticotropic Hormone - blood
Adult
Cortisol
Endocrinology & Metabolism
Female
Gonadal Steroid Hormones - blood
Humans
Hydrocortisone - metabolism
Hypothalamo-Hypophyseal System - physiology
Male
Menstrual Cycle - physiology
Menstrual Cycle - psychology
Pituitary-Adrenal System - physiology
Progesterone
Psychiatry
Saliva - metabolism
Sex Characteristics
Sex differences
Stress
Stress, Psychological - blood
Stress, Psychological - physiopathology
Stress, Psychological - psychology
Testosterone
TSST
Young Adult
Testosterone
Sex differences
Cortisol
Progesterone
Stress
TSST
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Summary:Highlights • Healthy young men and women (in the follicular phase of the menstrual cycle) completed the Trier Social Stress Test. • Post-stress hypothalamic–pituitary–adrenal (HPA) axis hormone responses were greater in men than women. • Pre-stress testosterone levels were negatively associated with post-stress salivary cortisol response in men. • Pre-stress progesterone levels were negatively associated with post-stress ACTH and serum cortisol responses in women. • Pre-stress progesterone in men and estradiol in women were not associated with post-stress HPA axis response.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Mary Ann C. Stephens, Ph.D., 550 N. Broadway, Suite 115, Baltimore, MD 21205 USA, +1-410-955-9525, +1-410-614-7003 (fax), mchutua1@jhmi.edu
Pamela B. Mahon, Ph.D., 600 N. Wolfe St, Phipps 300, Baltimore, MD 21287 USA, +1-410-955-1382, +1-410-614-3676 (fax), pbelmon2@jhmi.edu
Mary E. McCaul, Ph.D., 550 N. Broadway, Suite 115, Baltimore, MD 21205 USA, +1-410-955-9526, +1-410-614-7003 (fax), betsymc@jhmi.edu
Joint first authors
Senior author
Gary S. Wand, M.D., 720 Rutland Ave., Ross Building, Rm 863, Baltimore, MD 21205 USA, +1-410-614-0056, +1-410-955-0841 (fax), gwand@jhmi.edu
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.12.021