The touchscreen operant platform for assessing executive function in rats and mice

This protocol details a subset of assays developed within the touchscreen platform to measure various aspects of executive function in rodents. Three main procedures are included: extinction, measuring the rate and extent of curtailing a response that was previously, but is no longer, associated wit...

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Published inNature protocols Vol. 8; no. 10; pp. 1985 - 2005
Main Authors Mar, Adam C, Horner, Alexa E, Nilsson, Simon R O, Alsiö, Johan, Kent, Brianne A, Kim, Chi Hun, Holmes, Andrew, Saksida, Lisa M, Bussey, Timothy J
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.10.2013
Nature Publishing Group
Subjects
631/1647/2198
631/1647/334/1874/345
631/1647/334/1874/486
631/378/1595
Analysis
Analytical Chemistry
Animals
Behavior
Biological Techniques
Cognition
Cognition & reasoning
Computational Biology/Bioinformatics
Executive Function
Executive function (Psychology)
Extinction (Learning)
Interactive computer systems
Laboratory Animal Science - instrumentation
Laboratory Animal Science - methods
Life Sciences
Memory
Mice
Microarrays
Neurosciences
Organic Chemistry
Protocol
Rats
Rodents
Software
User-Computer Interface
United Kingdom > UK
United States > US
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Summary:This protocol details a subset of assays developed within the touchscreen platform to measure various aspects of executive function in rodents. Three main procedures are included: extinction, measuring the rate and extent of curtailing a response that was previously, but is no longer, associated with reward; reversal learning, measuring the rate and extent of switching a response toward a visual stimulus that was previously not, but has become, associated with reward (and away from a visual stimulus that was previously, but is no longer, rewarded); and the 5-choice serial reaction time (5-CSRT) task, gauging the ability to selectively detect and appropriately respond to briefly presented, spatially unpredictable visual stimuli. These protocols were designed to assess both complementary and overlapping constructs including selective and divided visual attention, inhibitory control, flexibility, impulsivity and compulsivity. The procedures comprise part of a wider touchscreen test battery assessing cognition in rodents with high potential for translation to human studies.
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AUTHOR CONTRIBUTION STATEMENT: All authors contributed to the writing of this manuscript. A.C.M. coordinated this effort.
ISSN:1754-2189
1750-2799
1750-2799
DOI:10.1038/nprot.2013.123