Mortality by cryptococcosis in Brazil from 2000 to 2012: A descriptive epidemiological study

• Published in: PLoS neglected tropical diseases Vol. 13; no. 7; p. e0007569
• Main Authors: Alves Soares, Emmanuel, Lazera, Márcia Dos Santos, Wanke, Bodo, Faria Ferreira, Marcela de, Carvalhaes de Oliveira, Raquel Vasconcellos, Oliveira, Adeno Gonçalves, Coutinho, Ziadir Francisco
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2019; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; AIDS; AIDS (Disease); Biology and Life Sciences; Brazil - epidemiology; Child; Cryptococcosis; Cryptococcosis - complications; Cryptococcosis - history; Cryptococcosis - mortality; Death; Diagnosis; Epidemiologic Studies; Epidemiology; Fatalities; Female; Fungal infections; History, 21st Century; HIV; Human immunodeficiency virus; Humans; Information systems; Inhabitants; Lethality; Male; Males; Medicine and Health Sciences; Meningitis; Middle Aged; Mortality; Mycoses; Mycosis; Patient outcomes; People and places; Public health; Risk analysis; Risk Factors; Statistics; Tropical diseases; Visibility; Young Adult; Brazil; Rio de Janeiro Brazil; Africa; Latin America
• ISSN: 1935-2735; 1935-2727; 1935-2735
• DOI: 10.1371/journal.pntd.0007569

Cryptococcosis is a neglected and predominantly opportunistic mycosis that, in Brazil, poses an important public health problem, due to its late diagnosis and high lethality. The present study analysed cryptococcosis mortality in Brazil from January 2000 to December 2012, based on secondary data (Mortality Information System/SIM-DATASUS and IBGE). Out of 5,755 recorded deaths in which cryptococcosis was mentioned as one of the morbid states that contributed to death, two distinct groups emerged: 1,121 (19.5%) registered cryptococcosis as the basic cause of death, and 4,634 (80.5%) registered cryptococcosis associated with risk factors, mainly AIDS (75%), followed by other host risks (5.5%). The mortality rate by cryptococcosis as the basic cause was 6.19/million inhabitants, whereas the mortality rate by cryptococcosis as an associated cause was 25.19/million inhabitants. Meningitis was the predominant clinical form (80%), males were the more affected (69%), and 39.5 years old was the mean age. The highest mortality rate due to cryptococcosis as basic cause occurred in the state of Mato Grosso (10.96/million inhabitants). Mortality rates due to cryptococcosis as associated cause were highest in the states of Santa Catarina (70.41/million inhabitants) and Rio Grande do Sul (64.40/million inhabitants), both in the South Region. Southeast, Northeast and South showed significant time trends in mortality rates. This study is relevant because it shows the magnitude of cryptococcosis mortality linked to AIDS and removes the invisibility of a particular non-AIDS-related disease, accounting for almost 20% of all cryptococcosis deaths. It can also contribute to control and surveillance programs, beyond highlighting the urgent prioritization of early diagnosis and proper treatment to reduce the unacceptable mortality rate of this neglected mycosis in Brazil.