FOXOs, cancer and regulation of apoptosis

Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetyl...

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Bibliographic Details
Published inOncogene Vol. 27; no. 16; pp. 2312 - 2319
Main Authors Fu, Z, Tindall, D J
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 07.04.2008
Nature Publishing Group
Subjects
Acetylation
Animals
Apoptosis
Apoptosis - physiology
Bcl-2 protein
Bcl-x protein
BIM protein
BNIP3 protein
Cancer
Care and treatment
Causes of
Cell Biology
Cell fate
Deacetylation
DNA binding proteins
FasL protein
Forkhead protein
Forkhead Transcription Factors - physiology
Gene expression
Genetic aspects
Human Genetics
Humans
Internal Medicine
Ligands
Medicine
Medicine & Public Health
Mitochondria
Neoplasms - pathology
Neoplasms - physiopathology
Oncology
Phosphorylation
Physiological aspects
Properties
Protein interaction
Proteins
review
Signal transduction
TRAIL protein
Transcription factors
Ubiquitination
United States
FOXO
Forkhead
Bcl-2 family members
apoptosis
cancer
death receptor ligand
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Summary:Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetylation/deacetylation, ubiquitination and protein–protein interactions. As FOXO factors play a pivotal role in cell fate decision, mounting evidence suggests that FOXO factors function as tumor suppressors in a variety of cancers. FOXOs are actively involved in promoting apoptosis in a mitochondria-independent and -dependent manner by inducing the expression of death receptor ligands, including Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, and Bcl-2 family members, such as Bim, bNIP3 and Bcl-X L , respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer.
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ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2008.24