Circadian disruption and metabolic disease: Findings from animal models

Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one. This voluntarily decision to stay awake long into the evening hours leads to cir...

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Published inBaillière's best practice & research. Clinical endocrinology & metabolism Vol. 24; no. 5; pp. 785 - 800
Main Authors Arble, Deanna Marie, BA, Ramsey, Kathryn Moynihan, PhD, Bass, Joseph, MD, PhD, Turek, Fred W., PhD
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.10.2010
Subjects
Animals
Biological Clocks - physiology
Brain - physiopathology
cardio-metabolic disease
Circadian Rhythm - physiology
circadian rhythms
Disease Models, Animal
Endocrinology & Metabolism
energy metabolism
Humans
Metabolic Diseases - etiology
Metabolic Diseases - pathology
Metabolic Diseases - physiopathology
Models, Biological
Photoperiod
restricted feeding
shift work
Sleep Disorders, Circadian Rhythm - complications
Sleep Disorders, Circadian Rhythm - metabolism
Sleep Disorders, Circadian Rhythm - pathology
Sleep Disorders, Circadian Rhythm - physiopathology
shift work
circadian rhythms
cardio-metabolic disease
energy metabolism
restricted feeding
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Summary:Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one. This voluntarily decision to stay awake long into the evening hours leads to circadian disruption at the system, tissue, and cellular levels. These derangements are in turn associated with clinical impairments in metabolic processes and physiology. The use of animal models for circadian disruption provides an important opportunity to determine mechanisms by which disorganization in the circadian system can lead to metabolic dysfunction in response to genetic, environmental, and behavioral perturbations. Here we review recent key animal studies involving circadian disruption and discuss the possible translational implications of these studies for human health and particularly for the development of metabolic disease.
ISSN:1521-690X
1878-1594
1532-1908
DOI:10.1016/j.beem.2010.08.003