Swallowing‐related neural oscillation: an intracranial EEG study

• Published in: Annals of clinical and translational neurology Vol. 8; no. 6; pp. 1224 - 1238
• Main Authors: Hashimoto, Hiroaki, Takahashi, Kazutaka, Kameda, Seiji, Yoshida, Fumiaki, Maezawa, Hitoshi, Oshino, Satoru, Tani, Naoki, Khoo, Hui Ming, Yanagisawa, Takufumi, Yoshimine, Toshiki, Kishima, Haruhiko, Hirata, Masayuki
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2021; John Wiley and Sons Inc; Wiley
• Subjects: Adolescent; Adult; Beta Rhythm - physiology; Cerebral Cortex - physiopathology; Deglutition - physiology; Deglutition Disorders - physiopathology; Dysphagia; Electrocorticography; Electrodes; Electroencephalography; Epilepsy - physiopathology; Esophagus; Female; Gamma Rhythm - physiology; Humans; Male; Middle Aged; Software; Swallowing; Young Adult; Japan
• ISSN: 2328-9503; 2328-9503
• DOI: 10.1002/acn3.51344

Objective Swallowing is a unique movement due to the indispensable orchestration of voluntary and involuntary movements. The transition from voluntary to involuntary swallowing is executed within milliseconds. We hypothesized that the underlying neural mechanism of swallowing would be revealed by high‐frequency cortical activities. Methods Eight epileptic participants fitted with intracranial electrodes over the orofacial cortex were asked to swallow a water bolus and cortical oscillatory changes, including the high γ band (75–150 Hz) and β band (13–30 Hz), were investigated at the time of mouth opening, water injection, and swallowing. Results Increases in high γ power associated with mouth opening were observed in the ventrolateral prefrontal cortex (VLPFC) with water injection in the lateral central sulcus and with swallowing in the region along the Sylvian fissure. Mouth opening induced a decrease in β power, which continued until the completion of swallowing. The high γ burst of activity was focal and specific to swallowing; however, the β activities were extensive and not specific to swallowing. In the interim between voluntary and involuntary swallowing, swallowing‐related high γ power achieved its peak, and subsequently, the power decreased. Interpretation We demonstrated three distinct activities related to mouth opening, water injection, and swallowing induced at different timings using high γ activities. The peak of high γ power related to swallowing suggests that during voluntary swallowing phases, the cortex is the main driving force for swallowing as opposed to the brain stem.