Electrokinetic Preconcentration of Small Molecules Within Volumetric Electromagnetic Hotspots in Surface Enhanced Raman Scattering

The on‐chip integration of a preconcentration chamber for ultrasensitive surface‐enhanced Raman scattering (SERS) is shown. Small molecules are preconcentrated using 3D volumetric electromagnetic hotspots. The experimental results demonstrate an enhancement of the SERS signals of over two orders of...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 11; no. 21; pp. 2487 - 2492
Main Authors Park, Moonseong, Oh, Young-Jae, Park, Sang-Gil, Yang, Seung-Bum, Jeong, Ki-Hun
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 01.06.2015
Wiley Subscription Services, Inc
Subjects
Chambers
Charging
Electrokinetics
Fingerprinting
Hot spots
localized surface plasmon resonance
Nanostructure
Nanotechnology
Neurotransmitters
Raman scattering
sensors
surface-enhanced Raman scattering
Three dimensional
electrokinetics
sensors
localized surface plasmon resonance
surface-enhanced Raman scattering
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Summary:The on‐chip integration of a preconcentration chamber for ultrasensitive surface‐enhanced Raman scattering (SERS) is shown. Small molecules are preconcentrated using 3D volumetric electromagnetic hotspots. The experimental results demonstrate an enhancement of the SERS signals of over two orders of magnitude, which allows the fingerprinting of neurotransmitter molecules at the nanomolar level and furthers the selective detection of oppositely charged molecules. This on‐chip integration will provide new directions for ultrasensitive SERS applications.
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ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201402942