HtrA与子痫前期相关性的研究进展

子痫前期（preeclampsia）是妊娠期特有的疾病,目前仍是重要的公共卫生问题,是发展中国家孕产妇死亡的主要原因之一。研究表明子痫前期与细胞凋亡、血管痉挛、凝血系统激活、炎症反应等密切相关,其病理变化起始于胎盘浅着床和胎盘血管重铸障碍,导致胎盘组织的缺血缺氧,引起子痫前期的发生。HtrA（high temperature requirement A）系丝氨酸蛋白酶家族,该蛋白家族在细胞热休克、氧化应激、炎症、缺血再灌注和肿瘤等应激条件下,降解细胞胞质内错误折叠的蛋白质,参与细胞凋亡、关节炎、胚胎形成、神经变性和神经肌肉障碍以及癌症等的病理生理过程,研究表明其亚型与子痫前期密切相关。总结近年...

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Bibliographic Details
Published in国际妇产科学杂志 Vol. 44; no. 1; pp. 56 - 59
Main Author 孔红芳 常亚清 王芳 辛虹
Format Journal Article
LanguageChinese
Published 河北医科大学第二医院妇产科, 石家庄,050000 2017
Subjects
HtrA
丝氨酸内肽酶类
先兆子痫
HtrA
Pre-eclampsia
Serine endopeptidases
丝氨酸内肽酶类
先兆子痫
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ISSN1674-1870

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Summary:子痫前期（preeclampsia）是妊娠期特有的疾病,目前仍是重要的公共卫生问题,是发展中国家孕产妇死亡的主要原因之一。研究表明子痫前期与细胞凋亡、血管痉挛、凝血系统激活、炎症反应等密切相关,其病理变化起始于胎盘浅着床和胎盘血管重铸障碍,导致胎盘组织的缺血缺氧,引起子痫前期的发生。HtrA（high temperature requirement A）系丝氨酸蛋白酶家族,该蛋白家族在细胞热休克、氧化应激、炎症、缺血再灌注和肿瘤等应激条件下,降解细胞胞质内错误折叠的蛋白质,参与细胞凋亡、关节炎、胚胎形成、神经变性和神经肌肉障碍以及癌症等的病理生理过程,研究表明其亚型与子痫前期密切相关。总结近年来与子痫前期有关的HtrA的研究进展及其介导的调控网络,对进一步了解子痫前期的发病机制及提供新的治疗途径有重要意义。
Bibliography:KONG Hong-fang, CHANG Ya-qing, WANG Fang,XIN Hong.（ Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China）
12-1399/R
Pre-eclampsia; Serine endopeptidases; HtrA
Pre-eclampsia, a major cause of maternal mortality in developing countries, is a peculiar disease during pregnancy. It still holds a central public health concern. Studies have shown that pre-eclampsia is closely related to the cell apoptosis, vasospasm, activation of blood coagulation system, inflammatory reaction and so on. Its pathological change began in the shallow placenta implantation and placental vascular recasting barriers, lead to the placenta tissue ischemia hypoxia, cause endothelial cell damage. High temperature requirement A（HtrA） is one of serine protease family, under stress conditions such as cells to heat shock, oxidative stress, inflammation, ischemia-reperfusion and cancer, degradation of misfolded proteins in the cell cytoplasm, participate in the pathological physiologic
ISSN:1674-1870