Inhibition of Erythroid Progenitor Cells by Anti-Kell Antibodies in Fetal Alloimmune Anemia

The Kell blood-group system is one of the major antigenic systems in human red cells. It consists of 23 known antigens that reside on one 93-kd transmembrane protein encoded by a single gene on chromosome 7 (7q33). 1 , 2 The Kell antigen is expressed only by erythroid progenitor cells and mature ery...

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Published inThe New England journal of medicine Vol. 338; no. 12; pp. 798 - 803
Main Authors Vaughan, Janet I, Manning, Monica, Warwick, Ruth M, Letsky, Elizabeth A, Murray, Neil A, Roberts, Irene A.G
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 19.03.1998
Subjects
Anemia
Anemia, Hemolytic, Autoimmune
Anemias. Hemoglobinopathies
Antibodies, Monoclonal - physiology
Biological and medical sciences
Cell Division - immunology
Cells
Diseases of red blood cells
Erythroblastosis, Fetal - blood
Erythroblastosis, Fetal - etiology
Erythroblastosis, Fetal - immunology
Erythroid Precursor Cells - immunology
Erythroid Precursor Cells - physiology
Erythropoiesis - immunology
Female
Fetal Blood - immunology
Fetuses
Hematologic and hematopoietic diseases
Hematopoietic Stem Cells - physiology
Humans
Immunity (Disease)
Infant, Newborn
Isoantibodies - physiology
Kell Blood-Group System - immunology
Medical research
Medical sciences
Pregnancy
Rh-Hr Blood-Group System - immunology
Severity of Illness Index
Immunopathology
Evaluation
Erythroid cell
Congenital
Antibody
Dyserythropoietic anemia
Hemopathy
Serology
In vitro
Kell system
Genetic disease
Fetus
Blood cell count
Comparative study
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Summary:The Kell blood-group system is one of the major antigenic systems in human red cells. It consists of 23 known antigens that reside on one 93-kd transmembrane protein encoded by a single gene on chromosome 7 (7q33). 1 , 2 The Kell antigen is expressed only by erythroid progenitor cells and mature erythroid cells. 1 , 3 , 4 The Kell blood group is important in clinical medicine because antibodies to the principal antigen, K1, cause both life-threatening transfusion reactions and severe alloimmune anemia in Kell-positive fetuses and newborn infants. 5 , 6 Alloimmunization occurs when Kell-negative women, who do not have the K1 antigen on their . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199803193381204