Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population

• Published in: PloS one Vol. 4; no. 7; p. e6423
• Main Authors: Cai, Xiao-yun, Wang, Xiao-feng, Li, Shi-lin, Qian, Ji, Qian, De-gui, Chen, Fei, Yang, Ya-jun, Yuan, Zi-yu, Xu, Jun, Bai, Yidong, Yu, Shun-zhang, Jin, Li
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.07.2009; Public Library of Science (PLoS)
• Subjects: Aged; Analysis; Cardiovascular disease; China; Deoxyribonucleic acid; DNA; DNA, Mitochondrial - genetics; Female; Females; Genetic engineering; Genetic polymorphisms; Genetics and Genomics/Complex Traits; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Medical Genetics; Geriatrics; Haplotypes; Humans; Longevity; Male; Middle Aged; Mitochondrial DNA; Mutation; Older people; Polymorphism, Single Nucleotide; Population studies; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0006423

Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity. To explore the effects of mtDNA haplogroups on the prevalence of extreme longevity (EL), a population based case-control study was conducted in Rugao--a prefecture city in Jiangsu, China. Case subjects include 463 individuals aged > or = 95 yr (EL group). Control subjects include 926 individuals aged 60-69 years (elderly group) and 463 individuals aged 40-49 years (middle-aged group) randomly recruited from Rugao. We observed significant reduction of M9 haplogroups in longevity subjects (0.2%) when compared with both elderly subjects (2.2%) and middle-aged subjects (1.7%). Linear-by-linear association test revealed a significant decreasing trend of N9 frequency from middle-aged subjects (8.6%), elderly subjects (7.2%) and longevity subjects (4.8%) (p = 0.018). In subsequent analysis stratified by gender, linear-by-linear association test revealed a significant increasing trend of D4 frequency from middle-aged subjects (15.8%), elderly subjects (16.4%) and longevity subjects (21.7%) in females (p = 0.025). Conversely, a significant decreasing trend of B4a frequency was observed from middle-aged subjects (4.2%), elderly subjects (3.8%) and longevity subjects (1.7%) in females (p = 0.045). Our observations support the association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.