Chronic hyperadiponectinemia induced by transgenic overexpression increases plasma exosomes without significantly improving glucose and lipid metabolism
The fat-derived factor, adiponectin, is considered a salutary circulating factor. We recently demonstrated that native adiponectin binds T-cadherin and promotes intracellular biogenesis and secretion of the exosome. Exosomes play important roles in various aspects of homeostasis, including glucose a...
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| Published in | ENDOCRINE JOURNAL Vol. 70; no. 6; pp. 635 - 645 |
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2023
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| Abstract | The fat-derived factor, adiponectin, is considered a salutary circulating factor. We recently demonstrated that native adiponectin binds T-cadherin and promotes intracellular biogenesis and secretion of the exosome. Exosomes play important roles in various aspects of homeostasis, including glucose and energy metabolism. However, it remains unclear whether and how the promotion of exosome production by adiponectin in vivo is beneficial for glucose and lipid metabolism. In the present study, overexpression of human adiponectin in mice resulted in an increased number of circulating exosomes, but it did not significantly improve glucose metabolism, change body weights, or change triglyceride clearance under a high-fat diet. Multiple small doses of streptozotocin increased blood glucose and decreased triglyceride clearance similarly in both wild-type and transgenic mice. Thus, these results indicated that human adiponectin overexpression in mice increases plasma exosomes but does not significantly influence glucose and lipid metabolism. |
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| AbstractList | The fat-derived factor, adiponectin, is considered a salutary circulating factor. We recently demonstrated that native adiponectin binds T-cadherin and promotes intracellular biogenesis and secretion of the exosome. Exosomes play important roles in various aspects of homeostasis, including glucose and energy metabolism. However, it remains unclear whether and how the promotion of exosome production by adiponectin in vivo is beneficial for glucose and lipid metabolism. In the present study, overexpression of human adiponectin in mice resulted in an increased number of circulating exosomes, but it did not significantly improve glucose metabolism, change body weights, or change triglyceride clearance under a high-fat diet. Multiple small doses of streptozotocin increased blood glucose and decreased triglyceride clearance similarly in both wild-type and transgenic mice. Thus, these results indicated that human adiponectin overexpression in mice increases plasma exosomes but does not significantly influence glucose and lipid metabolism. [Abstract.] The fat-derived factor, adiponectin, is considered a salutary circulating factor. We recently demonstrated that native adiponectin binds T-cadherin and promotes intracellular biogenesis and secretion of the exosome. Exosomes play important roles in various aspects of homeostasis, including glucose and energy metabolism. However, it remains unclear whether and how the promotion of exosome production by adiponectin in vivo is beneficial for glucose and lipid metabolism. In the present study, overexpression of human adiponectin in mice resulted in an increased number of circulating exosomes, but it did not significantly improve glucose metabolism, change body weights, or change triglyceride clearance under a high-fat diet. Multiple small doses of streptozotocin increased blood glucose and decreased triglyceride clearance similarly in both wild-type and transgenic mice. Thus, these results indicated that human adiponectin overexpression in mice increases plasma exosomes but does not significantly influence glucose and lipid metabolism. |
| ArticleNumber | EJ22-0665 |
| Author | Okita, Tomonori Otabe, Shuichi Kimura, Yu Fujii, Kohei Nishizawa, Hitoshi Kawada, Keitaro Fujishima, Yuya Maeda, Norikazu Fukuda, Shiro Kita, Shunbun Fukuoka, Keita Kawachi, Yusuke Kawada-Horitani, Emi Sakaue, Taka-aki Iioka, Masahito Shimomura, Iichiro |
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| References | 37 Yamauchi T, Iwabu M, Okada-Iwabu M, Kadowaki T (2014) Adiponectin receptors: a review of their structure, function and how they work. Best Pract Res Clin Endocrinol Metab 28: 15–23. 44 Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, et al. (2013) A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503: 493–499. 28 Matsuda K, Fujishima Y, Maeda N, Mori T, Hirata A, et al. (2015) Positive feedback regulation between adiponectin and T–cadherin impacts adiponectin levels in tissue and plasma of male mice. Endocrinology 156: 934–946. 35 Kita S, Shimomura I (2021) Stimulation of exosome biogenesis by adiponectin, a circulating factor secreted from adipocytes. J Biochem 169: 173–179. 6 Kita S, Maeda N, Shimomura I (2019) Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome. J Clin Invest 129: 4041–4049. 27 Xia JY, Sun K, Hepler C, Ghaben AL, Gupta RK, et al. (2018) Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice. Diabetologia 61: 932–941. 29 Qiao L, Wattez JS, Lee S, Guo Z, Schaack J, et al. (2016) Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1. Diabetologia 59: 2417–2425. 20 Nakamura Y, Kita S, Tanaka Y, Fukuda S, Obata Y, et al. (2020) Adiponectin stimulates exosome release to enhance mesenchymal stem-cell-driven therapy of heart failure in mice. Mol Ther 28: 2203–2219. 8 Maeda N, Funahashi T, Matsuzawa Y, Shimomura I (2020) Adiponectin, a unique adipocyte-derived factor beyond hormones. Atherosclerosis 292: 1–9. 11 Ma K, Cabrero A, Saha PK, Kojima H, Li L, et al. (2002) Increased β-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem 277: 34658–34661. 4 Lehr S, Hartwig S, Lamers D, Famulla S, Müller S, et al. (2012) Identification and validation of novel adipokines released from primary human adipocytes. Mol Cell Proteomics 11: M111.010504. 10 Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277: 25863–25866. 12 Streeper RS, Koliwad SK, Villanueva CJ, Farese RV Jr (2006) Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. Am J Physiol Endocrinol Metab 291: E388–E394. 16 Menzaghi C, Trischitta V (2018) The adiponectin paradox for all-cause and cardiovascular mortality. Diabetes 67: 12–22. 24 Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, et al. (2003) Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem 278: 40352–40363. 41 Santovito D, De Nardis V, Marcantonio P, Mandolini C, Paganelli C, et al. (2014) Plasma exosome microRNA profiling unravels a new potential modulator of adiponectin pathway in diabetes: effect of glycemic control. J Clin Endocrinol Metab 99: E1681–E1685. 14 Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, et al. (2004) A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 145: 367–383. 39 Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6: 772–783. 49 Tullin S, Sams A, Brandt J, Dahl K, Gong W, et al. (2012) Recombinant adiponectin does not lower plasma glucose in animal models of type 2 diabetes. PLoS One 7: e44270. 5 Lehr S, Hartwig S, Sell H (2012) Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteomics Clin Appl 6: 91–101. 31 Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, et al. (2008) Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319: 1244–1247. 42 Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941–946. 26 Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, et al. (2003) Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem 278: 50810–50817. 13 Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, et al. (2006) Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γ agonists. J Biol Chem 281: 2654–2660. 7 Wang ZV, Scherer PE (2016) Adiponectin, the past two decades. J Mol Cell Biol 8: 93–100. 18 Nielsen MB, Çolak Y, Benn M, Nordestgaard BG (2020) Causal relationship between plasma adiponectin and body mass index: one- and two-sample bidirectional mendelian randomization analyses in 460 397 individuals. Clin Chem 66: 1548–1557. 47 Waki H, Yamauchi T, Kamon J, Kita S, Ito Y, et al. (2005) Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology 146: 790–796. 23 Fukuda S, Kita S, Obata Y, Fujishima Y, Nagao H, et al. (2017) The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2. J Biol Chem 292: 7840–7849. 48 Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, et al. (2013) Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab 17: 534–548. 33 Tanaka Y, Kita S, Nishizawa H, Fukuda S, Fujishima Y, et al. (2019) Adiponectin promotes muscle regeneration through binding to T-cadherin. Sci Rep 9: 16. 25 Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, et al. (2003) Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 278: 9073–9085. 34 Tsugawa-Shimizu Y, Fujishima Y, Kita S, Minami S, Sakaue TA, et al. (2021) Increased vascular permeability and severe renal tubular damage after ischemia-reperfusion injury in mice lacking adiponectin or T-cadherin. Am J Physiol Endocrinol Metab 320: E179–E190. 19 Obata Y, Kita S, Koyama Y, Fukuda S, Takeda H, et al. (2018) Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release. JCI Insight 3: e99680. 2 Mathieu M, Martin-Jaular L, Lavieu G, Thery C (2019) Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol 21: 9–17. 9 Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731–737. 32 van Niel G, Charrin S, Simoes S, Romao M, Rochin L, et al. (2011) The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell 21: 708–721. 36 Straub LG, Scherer PE (2019) Metabolic Messengers: adiponectin. Nat Metab 1: 334–339. 45 Xu H, Zhao Q, Song N, Yan Z, Lin R, et al. (2020) AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis. Nat Commun 11: 5807. 22 Sachs S, Bastidas-Ponce A, Tritschler S, Bakhti M, Bottcher A, et al. (2020) Targeted pharmacological therapy restores beta-cell function for diabetes remission. Nat Metab 2: 192–209. 17 Borges MC, Lawlor DA, de Oliveira C, White J, Horta BL, et al. (2016) Role of adiponectin in coronary heart disease risk: a mendelian randomization study. Circ Res 119: 491–499. 3 Halberg N, Wernstedt-Asterholm I, Scherer PE (2008) The adipocyte as an endocrine cell. Endocrinol Metab Clin North Am 37: 753–768, x–xi. 21 Otabe S, Yuan X, Fukutani T, Wada N, Hashinaga T, et al. (2007) Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet. Am J Physiol Endocrinol Metab 293: E210–E218. 30 Baietti MF, Zhang Z, Mortier E, Melchior A, Degeest G, et al. (2012) Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat Cell Biol 14: 677–685. 38 Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, et al. (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257: 79–83. 1 Witwer KW, Thery C (2019) Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature. J Extracell Vesicles 8: 1648167. 43 Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423: 762–769. 40 Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, et al. (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46: 459–469. 46 Lee Y, Nakano A, Nakamura S, Sakai K, Tanaka M, et al. (2021) In vitro and in silico characterization of adiponectin-receptor agonist dipeptides. NPJ Sci Food 5: 29. 15 Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert MF, et al. (2013) Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 62: 3589–3598. 44 45 46 47 48 49 10 11 12 13 14 15 16 17 18 1 2 3 4 5 6 7 8 9 20 21 22 23 24 25 26 27 28 29 Y Obata (19) 2018; 3 30 31 32 33 34 35 36 37 38 39 40 41 42 43 |
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| Title | Chronic hyperadiponectinemia induced by transgenic overexpression increases plasma exosomes without significantly improving glucose and lipid metabolism |
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| ispartofPNX | Endocrine Journal, 2023, Vol.70(6), pp.635-645 |
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