Demographics, Management, and In-Hospital Outcome of Hospitalized Acute Heart Failure Syndrome Patients in Contemporary Real Clinical Practice in Japan　― Observations From the Prospective, Multicenter Kyoto Congestive Heart Failure (KCHF) Registry

• Published in: Circulation Journal Vol. 82; no. 11; pp. 2811 - 2819
• Main Authors: Yaku, Hidenori, Ozasa, Neiko, Morimoto, Takeshi, Inuzuka, Yasutaka, Tamaki, Yodo, Yamamoto, Erika, Yoshikawa, Yusuke, Kitai, Takeshi, Taniguchi, Ryoji, Iguchi, Moritake, Kato, Masashi, Takahashi, Mamoru, Jinnai, Toshikazu, Ikeda, Tomoyuki, Nagao, Kazuya, Kawai, Takafumi, Komasa, Akihiro, Nishikawa, Ryusuke, Kawase, Yuichi, Morinaga, Takashi, Su, Kanae, Kawato, Mitsunori, Sasaki, Kenichi, Toyofuku, Mamoru, Furukawa, Yutaka, Nakagawa, Yoshihisa, Ando, Kenji, Kadota, Kazushige, Shizuta, Satoshi, Ono, Koh, Sato, Yukihito, Kuwahara, Koichiro, Kato, Takao, Kimura, Takeshi, on behalf of the KCHF Study Investigators
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 25.10.2018
• Subjects: Acute Disease; Aged; Aged, 80 and over; Cohort study; Disease-Free Survival; Female; Heart failure; Heart Failure - mortality; Heart Failure - physiopathology; Heart Failure - therapy; Hospital Mortality; Hospitalization; Humans; Japan - epidemiology; Male; Mid-range ejection fraction; Mortality; Prospective Studies; Registries; Stroke Volume; Survival Rate; Syndrome; Japan; Heart failure; Hospitalization; Mid-range ejection fraction; Cohort study; Mortality
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-17-1386

Background: There is a scarcity of reports on the clinical characteristics and management practice in contemporary all-comer patients with acute decompensated heart failure (ADHF). Methods and Results: The Kyoto Congestive Heart Failure (KCHF) registry is a prospective observational cohort study enrolling 4,056 consecutive patients who had hospital admission due to ADHF without any exclusion criteria between October 2014 and March 2016 in the 19 participating hospitals in Japan. Baseline characteristics, clinical presentations, management, and in-hospital outcomes were compared between heart failure (HF) with reduced left ventricular ejection fraction (LVEF; HFrEF, LVEF <40%), HF with mid-range LVEF (HFmrEF, LVEF 40–49%), and HF with preserved LVEF (HFpEF, LVEF ≥50%). Of the 4,041 patients with documented LVEF, 1,744 (43%) had HFpEF; 746 (19%), HFmrEF; and 1,551 (38%), HFrEF. The median age was 80 years (IQR, 72–86 years) in the entire population, and was higher with increasing LVEF (P<0.001). The in-hospital mortality rate was higher in the HFrEF than in the HFmrEF and HFpEF groups (9.2%, 4.8%, and 5.1%, respectively, P<0.001). Conclusions: This registry elucidated the clinical features and clinically relevant in-hospital outcomes in contemporary consecutive patients with ADHF in real-world clinical practice in Japan. When classified by LVEF, significant differences in characteristics and in-hospital outcomes existed between patients with HFrEF, HFmrEF, and HFpEF.