Immune modules shared by innate lymphoid cells and T cells

• Published in: Journal of allergy and clinical immunology Vol. 138; no. 5; pp. 1243 - 1251
• Main Authors: Robinette, Michelle L., Colonna, Marco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016; Elsevier Limited
• Subjects: Accreditation; adaptive; Allergy and Immunology; Animals; Antigens; Bacterial Infections - immunology; Copyright; Cytokines; Cytotoxicity; Disclosure; Gene expression; Health education; Helminthiasis - immunology; Homeostasis; Human subjects; Humans; Immunity, Innate; innate; Innate lymphoid cell; lymphocyte; Lymphocytes; Lymphocytes - immunology; Mycoses - immunology; Rodents; T cell receptors; T cell; Virus Diseases - immunology; ILC; TCR; TRAIL; Innate lymphoid cell; innate; Treg; AHR; T-bet; lymphocyte; NFAT; ILC2; adaptive; Eomes; ILC3; STAT; TF; ILC1; ROR; T cell; NK; Signal transducer and activator of transcription; T-cell receptor; Regulatory T; Type 1 innate lymphoid cell; TNF-related apoptosis-inducing ligand; Transcription factor; Retinoic acid–related orphan receptor; Nuclear factor of activated T cells; Eomesodermin; Type 3 innate lymphoid cell; Aryl hydrocarbon receptor; Natural killer; Type 2 innate lymphoid cell; T-box transcription factor
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2016.09.006

In recent years, innate lymphoid cells (ILCs) have emerged as innate correlates to T cells. The similarities between ILCs and T cells indicate that lymphocytes of fundamentally distinct lineages can share core “immune modules” that encompass transcriptional circuitry and effector functions while using nonredundant complementary mechanisms of pattern recognition to enact these functions. We review modules currently recognized to be shared between ILCs and T cells.