Serum High-Sensitivity C-Reactive Protein Levels and the Development of Atrial Fibrillation in a General Japanese Population　― The Hisayama Study

Background:Atrial fibrillation (AF) is a common arrhythmia in the elderly, and causes complications such as cardioembolic stroke. Serum high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, has been reported to be a risk factor for developing AF in Western countries. Howev...

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Published inCirculation Journal Vol. 85; no. 8; pp. 1365 - 1372
Main Authors Yoshikawa, Tomoko, Hata, Jun, Sakata, Satoko, Nagata, Takuya, Hirakawa, Yoichiro, Hirooka, Yoshitaka, Tsutsui, Hiroyuki, Kitazono, Takanari, Ninomiya, Toshiharu
Format Journal Article
LanguageEnglish
Published Japan The Japanese Circulation Society 21.07.2021
Subjects
Aged
Atrial fibrillation
Atrial Fibrillation - epidemiology
Atrial Fibrillation - etiology
Biomarker
Biomarkers
C-Reactive Protein - analysis
Cohort study
Female
High-sensitivity C-reactive protein
Humans
Japan - epidemiology
Male
Proportional Hazards Models
Risk Factors
Japan
Biomarker
High-sensitivity C-reactive protein
Atrial fibrillation
Cohort study
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Summary:Background:Atrial fibrillation (AF) is a common arrhythmia in the elderly, and causes complications such as cardioembolic stroke. Serum high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, has been reported to be a risk factor for developing AF in Western countries. However, few community-based studies have examined this issue in general Asian populations.Methods and Results:A total of 2,510 community-dwelling Japanese participants aged ≥40 years without a history of AF were divided into 4 groups according to the sex-specific quartiles of serum hs-CRP concentrations (Q1, lowest and Q4, highest) and followed up for 24 years. The hazard ratios and their 95% confidence intervals for the development of AF were estimated using a Cox proportional hazards model. During the follow up, 234 subjects developed AF. The risk of AF increased significantly with elevating serum hs-CRP levels after adjustment for potential confounding factors (hazard ratio [95% confidence interval], Q1, 1.00 [reference]; Q2, 1.26 [0.83–1.92]; Q3, 1.77 [1.18–2.66]; and Q4, 1.89 [1.24–2.86]; P for trend <0.001).Conclusions:The study findings suggest that elevated serum hs-CRP levels are an independent risk factor for the development of AF in a general Japanese population.
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ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-20-0751