Prediction of bone loss using biochemical markers of bone turnover

• Published in: Osteoporosis international Vol. 18; no. 9; pp. 1297 - 1305
• Main Authors: LENORA, J, IVASKA, K. K, OBRANT, K. J, GERDHEM, P
• Format: Journal Article
• Language: English
• Published: London Springer 01.09.2007; Springer Nature B.V
• Subjects: Aged; Biochemistry; Biological and medical sciences; Biomarkers - metabolism; Bone density; Bone Density - physiology; bone loss; Bone Remodeling - physiology; Bone Resorption - metabolism; bone turnover markers; Clinical Medicine; Diagnostic tests; Diseases of the osteoarticular system; elderly; Female; Fractures, Bone - metabolism; Fundamental and applied biological sciences. Psychology; Humans; Kirurgi; Klinisk medicin; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Older people; Orthopedics; Ortopedi; Osteoporosis; Osteoporosis. Osteomalacia. Paget disease; Predictive Value of Tests; Prospective Studies; Skeleton and joints; Surgery; Vertebrates: osteoarticular system, musculoskeletal system; Women; Human; Osteoporosis; Diseases of the osteoarticular system; Bone density; Bone; Bone remodeling; Predictive factor; Bone loss; Density; Elderly; Bone turnover markers; Osteopenia
• ISSN: 0937-941X; 1433-2965; 1433-2965
• DOI: 10.1007/s00198-007-0379-z

The association between baseline levels of eleven bone turnover markers and 5-year rate of bone density change was prospectively studied in a population-based sample of 601 75-year-old women. Several bone formation and resorption markers as well as urinary osteocalcin were modestly correlated to rate of bone density change. Prediction of bone loss by bone turnover markers (BTMs) has been investigated with conflicting results. There is limited information in the elderly. Eleven bone turnover markers were analyzed in 75-year old women in the OPRA study (n = 601) and compared to the 5-year change of areal bone mineral density (aBMD) in seven skeletal regions. Annual aBMD change varied between +0.4% (spine) and -2.0% (femoral neck). Significant associations (p < 0.01) were found for four different serum osteocalcins (S-OCs) (standardized regression coefficient -0.20 to -0.22), urinary deoxypyridinoline (-0.19), serum TRACP5b (-0.19), serum CTX-I (-0.21), two of the three urinary osteocalcins (U-OCs) (-0.16) and aBMD change of the leg region (derived from the total body measurement). After adjustment for baseline aBMD, associations were found for all S-OCs (-0.11 to -0.16), two of the three U-OCs (-0.14 to -0.16) and aBMD change at the total hip, and for three of the four S-OCs (-0.14 to -0.15), S-TRACP5b (-0.11), two of the three U-OCs (-0.14 to -0.15) and aBMD change at the femoral neck. There were no significant results concerning aBMD change at the spine. This study indicates that BTMs are correlated with aBMD loss in some skeletal regions in elderly women.