Antiviral Amentoflavone from Selaginella sinensis

• Published in: Biological & pharmaceutical bulletin Vol. 24; no. 3; pp. 311 - 312
• Main Authors: MA, Shuang-Cheng, BUT, Paul Pui-Hay, OOI, Vincent Eng-Choon, HE, Yue-Hua, LEE, Spencer Hon-Sun, LEE, Song-Fong, LIN, Rui-Chao
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 2001; Maruzen; Japan Science and Technology Agency
• Subjects: amentoflavone; anti-RSV activity; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; Biflavonoids; Biological and medical sciences; China; Chromatography, High Pressure Liquid; Flavonoids - isolation & purification; Flavonoids - pharmacology; General pharmacology; HPLC; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal - chemistry; Respiratory Syncytial Virus, Human - drug effects; Selaginella sinensis; Species Specificity; Spectrophotometry, Ultraviolet; Tumor Cells, Cultured; China; Human respiratory syncytial virus; Pneumovirinae; Flavones; Drug susceptibility test; Pharmacognosy; HPLC chromatography; In vitro; Biological activity; Paramyxoviridae; Medicinal plant; Virus; Mononegavirales; Reversed phase chromatography; Structure activity relation; Plant origin; Separation process; Antiviral; Pneumovirus
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.24.311

Amentoflavone and three other flavonoids were isolated from the ethanol extract of Selaginella sinensis. Amentoflavone showed potent antiviral activity against respiratory syncytial virus (RSV), with an IC50 of 5.5 μg/ml. The contents of amentoflavone in nine species of Selaginella were determined by reversed-phase HPLC. S. sinensis showed a higher content of 1.13%.