Chronic stress, inflammation, and glucose regulation in U.S. Hispanics from the HCHS/SOL Sociocultural Ancillary Study

Diabetes prevalence is rising rapidly, and diabetes disproportionately affects Hispanics and other underserved groups. Chronic stress may contribute to diabetes risk, but few studies have examined this relationship in U.S. Hispanics. We examined associations of chronic stress with fasting glucose, g...

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Published inPsychophysiology Vol. 52; no. 8; pp. 1071 - 1079
Main Authors McCurley, Jessica L., Mills, Paul J., Roesch, Scott C., Carnethon, Mercedes, Giacinto, Rebeca E., Isasi, Carmen R., Teng, Yanping, Sotres-Alvarez, Daniela, Llabre, Maria M., Penedo, Frank J., Schneiderman, Neil, Gallo, Linda C.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.08.2015
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Summary:Diabetes prevalence is rising rapidly, and diabetes disproportionately affects Hispanics and other underserved groups. Chronic stress may contribute to diabetes risk, but few studies have examined this relationship in U.S. Hispanics. We examined associations of chronic stress with fasting glucose, glucose tolerance, and glycosylated hemoglobin (HbA1c) in Hispanics without diabetes, and also assessed indirect effects of stress through inflammation (CRP). Participants were 3,923 men and women, aged 18–74, without diabetes, from the four U.S. field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA) of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary study. Participants completed a measure of chronic life stress and a physical exam with oral glucose tolerance test. In a multivariate regression analysis with adjustment for demographic and health covariates, higher chronic stress was related to higher fasting glucose (standardized regression coefficient: β = .09, p < .01), postload glucose (β = .07, p < .05), and HbA1c levels (β = .08, p < .01). However, there was no indirect effect of stress through inflammation. Findings suggest that higher chronic stress is associated with poorer glucose regulation in Hispanics, prior to the onset of a clinical diabetes diagnosis.
Bibliography:University of Miami - No. N01-HC65234
National Institute of Neurological Disorders and Stroke
National Heart, Lung, and Blood Institute (NHLBI)
istex:9AB285AA8B3D1A46A5F71D77FDEF80ABAB7FE5A7
National Institute of Diabetes and Digestive and Kidney Diseases
National Center on Minority Health and Health Disparities
ArticleID:PSYP12430
Albert Einstein College of Medicine - No. N01-HC65235
San Diego State University - No. N01-HC65237
National Institute of Deafness and Other Communications Disorders
Office of Dietary Supplements
ark:/67375/WNG-628DQ4GC-0
National Institute of Dental and Craniofacial Research
University of North Carolina - No. N01-HC65233
MIH/NHLBI - No. RC2HL101649
Northwestern University - No. N01-HC65236
http://www.cscc.unc.edu/hchs
The Hispanic Community Health Study/Study of Latinos is a collaborative investigation supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01‐HC65233), University of Miami (N01‐HC65234), Albert Einstein College of Medicine (N01‐HC65235), Northwestern University (N01‐HC65236), and San Diego State University (N01‐HC65237). The following institutes/centers/offices also contributed to funding the HCHS/SOL through the NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. The HCHS/SOL Sociocultural Ancillary Study was supported by MIH/NHLBI grant number RC2HL101649 (PIs LCG and FJP). The authors thank the staff and participants of HCHS/SOL and the HCHS/SOL Sociocultural Ancillary Study for their important contributions. A complete list of staff and investigators is available on the study website at
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ISSN:0048-5772
1469-8986
1540-5958
DOI:10.1111/psyp.12430