Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles

• Published in: Science (American Association for the Advancement of Science) Vol. 227; no. 4687; pp. 640 - 642
• Main Authors: Williams, R.C, Jeffcoat, M.K, Kaplan, M.L, Goldhaber, P, Johnson, H.G, Wechter, W.J
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 08.02.1985; American Association for the Advancement of Science
• Subjects: Alveolar bone loss; Alveolar Process - drug effects; Alveolar Process - physiology; Animals; ANTI-INFLAMMATOIRE; ANTIINFLAMMATORY AGENTS; ANTINFLAMATORIOS; Beagles (Dogs); Biological and medical sciences; BONE DISEASES; Bone resorption; Bone Resorption - drug effects; Bones; Bones, joints and connective tissue. Antiinflammatory agents; Care and treatment; CHIEN; Diseases; Dog diseases; DOGS; Drug therapy; ENFERMEDADES OSEAS; Female; Flurbiprofen; Flurbiprofen - pharmacology; Flurbiprofen - therapeutic use; Humans; Medical sciences; Metabolic bone diseases; Metabolic diseases; OSTEOPATHIE; PARADONTAL DISEASE; Periodontal disease; Periodontal diseases; Periodontal Diseases - drug therapy; Periodontitis; PERRO; Pharmaceutical research; Pharmacology. Drug treatments; Placebos; Pretreatment; Propionates - pharmacology; Tooth diseases; TREATMENT; Non steroidal antiinflammatory agent; Fissipedia; Carnivora; Vertebrata; Mammalia; Periodontitis; Animal; Arachidonic acid derivatives; Alveolar bone; Mechanism of action; Dog; Prostaglandin synthase
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.3969553

The nonsteroidal anti-inflammatory drug, flurbiprofen, a potent cyclooxygenase inhibitor, significantly decreases the resorption of alveolar bone in naturally occurring chronic destructive periodontal disease in beagles. This observation indicates that arachidonic acid metabolites are important in the alveolar bone loss of periodontitis and suggests a use for flurbiprofen in the management of bone resorption disease.