Sexual Transmission of an HIV-1 Variant Resistant to Multiple Reverse-Transcriptase and Protease Inhibitors

• Published in: The New England journal of medicine Vol. 339; no. 5; pp. 307 - 311
• Main Authors: Hecht, Frederick M, Grant, Robert M, Petropoulos, Christos J, Dillon, Beth, Chesney, Margaret A, Tian, Huan, Hellmann, Nicholas S, Bandrapalli, Nirmala I, Digilio, Laura, Branson, Bernard, Kahn, James O
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 30.07.1998
• Subjects: AIDS/HIV; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; Case studies; Disease Transmission, Infectious; Drug resistance; Drug Resistance, Multiple - genetics; Drug therapy; Drug Therapy, Combination; HIV; HIV Infections - drug therapy; HIV Infections - transmission; HIV Infections - virology; HIV-1 - classification; HIV-1 - drug effects; HIV-1 - genetics; Human immunodeficiency virus; Humans; Male; Medical sciences; Middle Aged; Mutation; Pharmacology. Drug treatments; Protease Inhibitors - pharmacology; Protease Inhibitors - therapeutic use; Reverse Transcriptase Inhibitors - pharmacology; Reverse Transcriptase Inhibitors - therapeutic use; RNA, Viral - blood; RNA-Directed DNA Polymerase - genetics; Sexual Behavior; Human; Immunopathology; Enzyme; Transferases; Retroviridae; Male; AIDS; Immune deficiency; Lentivirus; DNA-directed RNA polymerase; Infection; Virus; Case study; Peptidases; Nucleotidyltransferases; Chemotherapy; Microorganism resistance; Sexually transmitted disease; Treatment; Viral disease; Hydrolases; Antiviral; Transmission from man to man; Human immunodeficiency virus
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199807303390504

Combination treatments with agents that inhibit protease and reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) decrease mortality and slow disease progression. 1 The development of resistance to these drugs, however, limits the benefit of such treatments. 2 , 3 There have been reports of the transmission of HIV-1 variants that are resistant to nucleoside and non-nucleoside inhibitors of reverse transcriptase. 4 – 9 The transmission of HIV-1 variants that are resistant to protease inhibitors could represent an important emerging clinical and public health problem. We report a case of transmission of an HIV-1 variant with multiple mutations that conferred resistance to both protease . . .