Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana

The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes associated with hybrid incompatibilities, often with limited success, suggestin...

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Bibliographic Details
Published inPloS one Vol. 5; no. 10; p. e15377
Main Authors Chang, Audrey S, Bennett, Sarah M, Noor, Mohamed A F
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 27.10.2010
Public Library of Science (PLoS)
Subjects
Analysis
Animals
Biology
Chromosome Mapping
Chromosomes
Diapheromera persimilis
Divergence
Drosophila
Drosophila persimilis
Drosophila pseudoobscura
Epistasis
Epistasis, Genetic
Evolution
Genes
Genetic aspects
Genetics
Genomes
Infertility
Infertility, Male - genetics
Insects
Male
Male sterility
Males
Mules
Quantitative genetics
Quantitative Trait Loci
Science
Studies
Yeast
North Carolina
New York
United States > US
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Summary:The Bateson-Dobzhansky-Muller model posits that hybrid incompatibilities result from genetic changes that accumulate during population divergence. Indeed, much effort in recent years has been devoted to identifying genes associated with hybrid incompatibilities, often with limited success, suggesting that hybrid sterility and inviability are frequently caused by complex interactions between multiple loci and not by single or a small number of gene pairs. Our previous study showed that the nature of epistasis between sterility-conferring QTL in the Drosophila persimilis-D. pseudoobscura bogotana species pair is highly specific. Here, we further dissect one of the three QTL underlying hybrid male sterility between these species and provide evidence for multiple factors within this QTL. This result indicates that the number of loci thought to contribute to hybrid dysfunction may have been underestimated, and we discuss how linkage and complex epistasis may be characteristic of the genetics of hybrid incompatibilities. We further pinpoint the location of one locus that confers hybrid male sterility when homozygous, dubbed "mule-like", to roughly 250 kilobases.
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Conceived and designed the experiments: ASC MAFN. Performed the experiments: ASC SMB. Analyzed the data: ASC MAFN. Contributed reagents/materials/analysis tools: ASC MAFN. Wrote the paper: ASC MAFN.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0015377