A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK

• Published in: Scientific reports Vol. 11; no. 1; p. 8412
• Main Authors: Zhang, Yuxuan, Gong, Chen, Li, Dawei, Wang, Zhi-Wei, Pu, Shengda D., Robertson, Alex W., Yu, Hong, Parrington, John
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/255; 692/699/255/2514; 692/700/478/174; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 - epidemiology; COVID-19 - prevention & control; COVID-19 - virology; Disease control; Disease transmission; Growth rate; Herd immunity; Humanities and Social Sciences; Humans; Infectious diseases; Models, Theoretical; multidisciplinary; Prognosis; Public health; SARS-CoV-2 - isolation & purification; Science; Science (multidisciplinary); United Kingdom - epidemiology; Vaccination; Vaccination - psychology; United Kingdom; United Kingdom > UK
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-87882-9

A reasonable prediction of infectious diseases’ transmission process under different disease control strategies is an important reference point for policy makers. Here we established a dynamic transmission model via Python and realized comprehensive regulation of disease control measures. We classified government interventions into three categories and introduced three parameters as descriptions for the key points in disease control, these being intraregional growth rate, interregional communication rate, and detection rate of infectors. Our simulation predicts the infection by COVID-19 in the UK would be out of control in 73 days without any interventions; at the same time, herd immunity acquisition will begin from the epicentre. After we introduced government interventions, a single intervention is effective in disease control but at huge expense, while combined interventions would be more efficient, among which, enhancing detection number is crucial in the control strategy for COVID-19. In addition, we calculated requirements for the most effective vaccination strategy based on infection numbers in a real situation. Our model was programmed with iterative algorithms, and visualized via cellular automata; it can be applied to similar epidemics in other regions if the basic parameters are inputted, and is able to synthetically mimic the effect of multiple factors in infectious disease control.