Metabolic Interaction Between Schwann Cells and Axons Under Physiological and Disease Conditions

Recent research into axon-glial interactions in the nervous system have made a compelling case that Schwann cells (SC) have a relevant role in the metabolic support of axons, and that this role is independent from myelination itself. In this mini-review we summarize some of those observations, point...

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Bibliographic Details
Published inFrontiers in cellular neuroscience Vol. 14; p. 148
Main Authors Bouçanova, Filipa, Chrast, Roman
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 29.05.2020
Frontiers Media S.A
Subjects
Apolipoproteins
axon
Cellular Neuroscience
Defects
energy metabolism
Insects
ketogenic diet
Lipids
Mammals
Medicin och hälsovetenskap
Metabolism
Mutation
Myelination
Nervous system
Neurodegeneration
Oxidative stress
peripheral neuropathy
Physiology
PNS
Proteins
Reviews
Schwann cell
Schwann cells
Therapeutic applications
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Summary:Recent research into axon-glial interactions in the nervous system have made a compelling case that Schwann cells (SC) have a relevant role in the metabolic support of axons, and that this role is independent from myelination itself. In this mini-review we summarize some of those observations, point out a few limitations and discuss the potential clinical relevance of this knowledge. First, we introduce SC, their development and main roles, and follow with an evolutionary perspective of their metabolic function. Then we provide evidence of the myelin-independent aspects of axonal support and of their coupling to neuronal metabolism. Finally, we address the opportunity to use SC-axon metabolic interactions as therapeutic targets to treat peripheral neuropathies.
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Reviewed by: Yannick Poitelon, Albany Medical College, United States; Felipe A. Court, Centro de Biología Integrativa, Universidad Mayor, Chile
Specialty section: This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience
Edited by: Marie-Eve Tremblay, University of Victoria, Canada
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2020.00148