Quantifying effect of geographic location on epidemiology of Plasmodium vivax malaria

Recent autochthonous transmission of Plasmodium vivax malaria in previously malaria-free temperate regions has generated renewed interest in the epidemiology of this disease. Accurate estimates of the incubation period and time to relapse are required for effective malaria surveillance; however, thi...

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Published inEmerging infectious diseases Vol. 19; no. 7; pp. 1058 - 1065
Main Authors Lover, Andrew A, Coker, Richard J
Format Journal Article
LanguageEnglish
Published United States U.S. National Center for Infectious Diseases 01.07.2013
Centers for Disease Control and Prevention
Subjects
Analysis
Disease-Free Survival
Epidemiology
Female
geographic location
Host-Parasite Interactions
Humans
Infection
Kaplan-Meier Estimate
Malaria
Malaria, Vivax - epidemiology
Malaria, Vivax - parasitology
Malaria, Vivax - prevention & control
Male
Multivariate Analysis
Plasmodium vivax
Plasmodium vivax - physiology
population surveillance
Recurrence
survival analysis
Tropical Climate
vivax
Western World
tropical
Plasmodium vivax
epidemiology
temperate
vector-borne infections
population surveillance
survival analysis
parasites
vivax
malaria
geographic location
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Summary:Recent autochthonous transmission of Plasmodium vivax malaria in previously malaria-free temperate regions has generated renewed interest in the epidemiology of this disease. Accurate estimates of the incubation period and time to relapse are required for effective malaria surveillance; however, this information is currently lacking. By using historical data from experimental human infections with diverse P. vivax strains, survival analysis models were used to obtain quantitative estimates of the incubation period and time to first relapse for P. vivax malaria in broad geographic regions. Results show that Eurasian strains from temperate regions have longer incubation periods, and Western Hemisphere strains from tropical and temperate regions have longer times to relapse compared with Eastern Hemisphere strains. The diversity in these estimates of key epidemiologic parameters for P. vivax supports the need for elucidating local epidemiology to inform clinical follow-up and to build an evidence base toward global elimination of malaria.
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ISSN:1080-6040
1080-6059
DOI:10.3201/eid1907.121674