Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair

• Published in: Neural regeneration research Vol. 12; no. 6; pp. 886 - 889
• Main Authors: Angelova, Angelina, Angelov, Borislav
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.06.2017; Medknow Publications & Media Pvt. Ltd; Institut Galien Paris-Sud, CNRS UMR 8612, University of Paris-Sud, Université Paris-Saclay, LabEx LERMIT, Chatenay-Malabry cedex, France%Institute of Physics, ELI Beamlines, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Amyotrophic lateral sclerosis; BDNF delivery; neuroprotective lipid nanocarriers; neurotrophic factor; CREB; nanomedicine; macromolecular drugs; combination therapy; BDNF基因; Brain-derived neurotrophic factor; Drugs; Gene expression; Invited Review; Kinases; Lipids; Mitochondria; Mutation; Nanoparticles; Nanotechnology; Neurodegeneration; Neurogenesis; Neurological disorders; Neurons; Oxidative stress; Peptides; Physiological aspects; Proteins; Reactive oxygen species; Synaptic transmission; 修复; 神经退行性疾病; 突触; 纳米颗粒; 细胞存活; 脑源性神经营养因子; 蛋白药物; CREB; macromolecular drugs; neurotrophic factor; BDNF delivery; combination therapy; nanomedicine; neuroprotective lipid nanocarriers
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.208546

Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor（BDNF） and its high-affinity tropomyosin-related kinase receptor（Trk B） present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB（c AMP response element-binding protein） has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF. We assume that BDNF delivery by nanocarriers and mitochondrial protection may provide high potential for therapeutic amelioration of the neuroregenerative strategies. Beneficial therapeutic outcomes may be expected for synergistic dual or multi-drug action aiming at（i） neurotrophic protein regulation in the central and peripheral nervous systems, and（ii） diminishment of the production of reactive oxygen species（ROS） and the oxidative damage in mitochondria. Our research strategy is based on a nanoarchitectonics approach for the design of nanomedicine assemblies by hierarchical self-assembly. We explore nanoarchitectonics concepts in soft-matter nanotechnology towards preparation of biodegradable self-assembled lipid nanostructures for safe neuro-therapeutic applications of multi-target nanomedicines.