Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy

• Published in: Neural regeneration research Vol. 12; no. 10; pp. 1655 - 1663
• Main Authors: Lv, Hong-yan, Wu, Su-jing, Wang, Qiu-li, Yang, Li-hong, Ren, Peng-shun, Qiao, Bao-jun, Wang, Zhi-ying, Li, Jia-hong, Gu, Xiu-ling, Li, Lian-xiang
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.10.2017; Medknow Publications & Media Pvt. Ltd; Department of Neural Development and Neural Pathology, Hebei University of Engineering School of Medicine, Handan, Hebei Province, China; Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China; Department of Neonatal Pathology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China%Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China%Department of Children's Rehabilitation, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China%Department of Neonatal Pathology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Anemia; Blood pressure; Brain damage; Care and treatment; Childrens health; Coma; Developmental neurology; Encephalopathy; Erythropoietin; Health aspects; Hemorrhage; Hypothermia; Hypoxia; Induced hypothermia; Intensive care; Maternal & child health; Medical research; Neonatal diseases; nerve regeneration; erythropoietin; hypothermia; hypoxic - ischemic encephalopathy; neonate; tau protein; biomarkers; prognosis; neuroprotection; neural regeneration; Patient outcomes; Proteins; Substance abuse treatment; tau; Tau proteins; Traumatic brain injury; 亚低温; 低体温; 促红细胞生成素; 新生儿; 神经发育; 缺氧缺血性脑病; 血清蛋白水平; China; neural regeneration; hypothermia; hypoxic-ischemic encephalopathy; biomarkers; neuroprotection; neonate; nerve regeneration; prognosis; tau protein; erythropoietin

Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy,many neonatal patients die or suffer from severe neurological dysfunction.Erythropoietin is considered one of the most promising neuroprotective agents.We hypothesized that erythropoietin combined with hypoth...