Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy

• Published in: Neural regeneration research Vol. 12; no. 10; pp. 1655 - 1663
• Main Authors: Lv, Hong-Yan, Wu, Su-Jing, Wang, Qiu-Li, Yang, Li-Hong, Ren, Peng-Shun, Qiao, Bao-Jun, Wang, Zhi-Ying, Li, Jia-Hong, Gu, Xiu-Ling, Li, Lian-Xiang
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.10.2017; Medknow Publications & Media Pvt. Ltd; Department of Neural Development and Neural Pathology, Hebei University of Engineering School of Medicine, Handan, Hebei Province, China; Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China; Department of Neonatal Pathology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China%Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China%Department of Children's Rehabilitation, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China%Department of Neonatal Pathology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Anemia; Blood pressure; Brain damage; Care and treatment; Childrens health; Coma; Developmental neurology; Encephalopathy; Erythropoietin; Health aspects; Hemorrhage; Hypothermia; Hypoxia; Induced hypothermia; Intensive care; Maternal & child health; Medical research; Neonatal diseases; nerve regeneration; erythropoietin; hypothermia; hypoxic - ischemic encephalopathy; neonate; tau protein; biomarkers; prognosis; neuroprotection; neural regeneration; Patient outcomes; Proteins; Substance abuse treatment; tau; Tau proteins; Traumatic brain injury; 亚低温; 低体温; 促红细胞生成素; 新生儿; 神经发育; 缺氧缺血性脑病; 血清蛋白水平; China; neural regeneration; hypothermia; hypoxic-ischemic encephalopathy; biomarkers; neuroprotection; neonate; nerve regeneration; prognosis; tau protein; erythropoietin
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.217338

Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy,many neonatal patients die or suffer from severe neurological dysfunction.Erythropoietin is considered one of the most promising neuroprotective agents.We hypothesized that erythropoietin combined with hypothermia will improve efficacy of neonatal hypoxic-ischemic encephalopathy treatment.In this study,41 neonates with moderate/severe hypoxic-ischemic encephalopathy were randomly divided into a control group（hypothermia alone for 72 hours,n = 20） and erythropoietin group（hypothermia ＋ erythropoietin 200 IU/kg for 10 days,n = 21）.Our results show that compared with the control group,serum tau protein levels were lower and neonatal behavioral neurological assessment scores higher in the erythropoietin group at 8 and 12 days.However,neurodevelopmental outcome was similar between the two groups at 9 months of age.These findings suggest that erythropoietin combined with hypothermia reduces serum tau protein levels and improves neonatal behavioral neurology outcome but does not affect long-term neurodevelopmental outcome.