Serum prealbumin as an effective prognostic indicator for determining clinical status and prognosis in patients with hemorrhagic stroke

• Published in: Neural regeneration research Vol. 12; no. 7; pp. 1097 - 1102
• Main Authors: Zhang, Shen-Qi, Peng, Bin, Stary, Creed M, Jian, Zhi-Hong, Xiong, Xiao-Xing, Chen, Qian-Xue
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.07.2017; Medknow Publications & Media Pvt. Ltd; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China%Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China%Department of Anesthesiology, Stanford University School of Medicine, Palo Alto, CA, USA; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Care and treatment; Diagnosis; Health aspects; Hemorrhage; Hemorrhagic shock; Hospitals; Infections; Inflammation; Liver; Magnetic resonance imaging; Medical prognosis; Mortality; nerve regeneration; prealbumin; hemorrhagic stroke; infection; gastrointestinal hemorrhage; prognostic indicator; prognosis; neural regeneration; Prealbumin; Prognosis; Proteins; Statistical analysis; Stroke; 临床; 出血性; 前白蛋白; 患者; 脑卒中; 蛋白水平; 血清; 预后判断; United States > US; infection; neural regeneration; prealbumin; gastrointestinal hemorrhage; prognostic indicator; hemorrhagic stroke; nerve regeneration; prognosis
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.211188

Serum prealbumin is a recognized marker of malnutrition,but its prognostic role in patients with hemorrhagic stroke remains unclear.In this study,we retrospectively reviewed the records of 105 patients with hemorrhagic stroke admitted to Renmin Hospital of Wuhan University,China,from January to December 2015.We collected demographic and radiological data,and recorded serum prealbumin levels at admission and on days 1,3,6,9,and 14-21.The existence of infections and gastrointestinal hemorrhage,and clinical condition at discharge were also recorded.Serum prealbumin levels during hospitalization were significantly lower in patients with infections compared with those without infections,and also significantly lower in patients with gastrointestinal hemorrhage compared with those without.Serum prealbumin levels at discharge were significantly higher in patients with good recovery than in those with poor recovery.We conclude that regular serum prealbumin measurements in patients with hemorrhagic stroke may be a useful indicator for determining clinical status and prognosis,which may therefore help to guide clinical decision-making.