Advances in regenerative therapies for spinal cord injury： a biomaterials approach

• Published in: Neural regeneration research Vol. 10; no. 5; pp. 726 - 742
• Main Author: Magdalini Tsintou Kyriakos Dalamagkas, Alexander Marcus Seifalian
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.05.2015; Medknow Publications & Media Pvt. Ltd; UCL Centre for Nanotechnology & Regenerative Medicine, Division of Surgery and Interventional Science, University College of London, London, UK; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: active zone stability; axon pathfinding; Biological products; biomaterial; biomaterials; Biomedical materials; brain; Brain research; Care and treatment; cell migration; cell transplant; central nervous system; Clinical trials; Cysts; dephosphorylation; Drosophila; Edema; GSK-3ß; Health aspects; injury; Invited Review; Ischemia; Liprin-α; living scaffolds; microglia; nanotechnology; neural progenitor; neural tissue engineering; neurodegeneration; neurodegenerative disease; neuromuscular junction; neuron; neuroregeneration; neurotrauma; Patients; plasticity; PP2A; regeneration; Regenerative medicine; repair; Spinal cord injuries; spinal cord injury; Stem cells; Syd-1; therapy; Tissue engineering; 中枢神经系统; 修复机制; 分子折叠; 损伤修复; 疗法; 神经再生; 经济问题; 脊髓损伤; United States; spinal cord injury; repair; tissue engineering; biomaterial; neuroregeneration; regenerative medicine; nanotechnology; central nervous system
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.156966

Spinal cord injury results in the permanent loss of function, causing enormous personal, social and economic problems. Even though neural regeneration has been proven to be a natural mech- anism, central nervous system repair mechanisms are ineffective due to the imbalance of the inhibitory and excitatory factors implicated in neuroregeneration. Therefore, there is growing re- search interest on discovering a novel therapeutic strategy for effective spinal cord injury repair. To this direction, cell-based delivery strategies, biomolecule delivery strategies as well as scaf- fold-based therapeutic strategies have been developed with a tendency to seek for the answer to a combinatorial approach of all the above. Here we review the recent advances on regenerativel neural engineering therapies for spinal cord injury, aiming at providing an insight to the most promising repair strategies, in order to facilitate future research conduction.