Hemodynamic study of TCPC using in vivo and in vitro 4D Flow MRI and numerical simulation

• Published in: Journal of biomechanics Vol. 48; no. 7; pp. 1325 - 1330
• Main Authors: Roldán-Alzate, Alejandro, García-Rodríguez, Sylvana, Anagnostopoulos, Petros V, Srinivasan, Shardha, Wieben, Oliver, François, Christopher J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.05.2015; Elsevier Limited
• Subjects: 4D Flow; Additive manufacturing; Adult; Anastomosis, Surgical; Biomedical materials; Cardiac Surgical Procedures - adverse effects; Child; Computational fluid dynamics; Congenital heart disease; Exports; Female; Geometry; Heart rate; Hemodynamics; Humans; Hydrodynamics; In vitro testing; In vivo testing; In vivo tests; Lasers; Magnetic Resonance Imaging; Male; Mathematical models; Numerical simulation; Patients; Physical Medicine and Rehabilitation; Pulmonary arteries; Pulmonary Artery - surgery; Rapid prototyping; Simulation; Studies; Surgical implants; Total cavopulmonary connection; Vena Cava, Inferior - surgery; Vena Cava, Superior - surgery; Total cavopulmonary connection; Numerical simulation; Congenital heart disease; Additive manufacturing; Magnetic resonance imaging; 4D Flow
• ISSN: 0021-9290; 1873-2380
• DOI: 10.1016/j.jbiomech.2015.03.009

Abstract Introduction: Altered total cavopulmonary connection (TCPC) hemodynamics can cause long-term complications. Patient-specific anatomy hinders generalized solutions. 4D Flow MRI allows in vivo assessment, but not predictions under varying conditions and surgical approaches. Computational fluid dynamics (CFD) improves understanding and explores varying physiological conditions. This study investigated a combination of 4D Flow MRI and CFD to assess TCPC hemodynamics, accompanied with in vitro measurements as CFD validation. 4D Flow MRI was performed in extracardiac and atriopulmonary TCPC subjects. Data was processed for visualization and quantification of velocity and flow. Three-dimensional (3D) geometries were generated from angiography scans and used for CFD and a physical model construction through additive manufacturing. These models were connected to a perfusion system, circulating water through the vena cavae and exiting through the pulmonary arteries at two flow rates. Models underwent 4D Flow MRI and image processing. CFD simulated the in vitro system, applying two different inlet conditions from in vitro 4D Flow MRI measurements; no-slip was implemented at rigid walls. Velocity and flow were obtained and analyzed. The three approaches showed similar velocities, increasing proportionally with high inflow. Atriopulmonary TCPC presented higher vorticity compared to extracardiac at both inflow rates. Increased inflow balanced flow distribution in both TCPC cases. Atriopulmonary IVC flow participated in atrium recirculation, contributing to RPA outflow; at baseline, IVC flow preferentially traveled through the LPA. The combination of patient-specific in vitro and CFD allows hemodynamic parameter control, impossible in vivo. Physical models serve as CFD verification and fine-tuning tools.