Fischerisin A and B, Cytotoxic Sesquiterpenoid-Geranylhydroquinones from Ligularia fischeri

During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS...

Full description

Saved in:
Bibliographic Details
Published inChemical & Pharmaceutical Bulletin Vol. 59; no. 4; pp. 511 - 514
Main Authors Xie, Wei-Dong, Li, Xia, Weng, Cheng-Wu, Liu, Shan-Shan, Row, Kyung Ho
Format Journal Article
LanguageEnglish
Japanese
Published TOKYO The Pharmaceutical Society of Japan 2011
Pharmaceutical Society of Japan
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - toxicity
Asteraceae - chemistry
Cell Line, Tumor
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
cytotoxicity
Drug Screening Assays, Antitumor
fischerisin A
fischerisin B
geranylhydroquinone
Humans
Life Sciences & Biomedicine
Ligularia fischeri
Magnetic Resonance Spectroscopy
Pharmacology & Pharmacy
Physical Sciences
Plant Roots - chemistry
Science & Technology
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Sesquiterpenes - toxicity
sesquiterpenoid
Spectrophotometry, Infrared
Terpenes - chemistry
Terpenes - isolation & purification
Terpenes - toxicity
fischerisin B
sesquiterpenoid
fischerisin A
LACTONES
Ligularia fischeri
geranylhydroquinone
cytotoxicity
Online AccessGet full text

Cover

More Information
Summary:During the course of screening natural sesquiterpenoids for new antitumor agents, two novel compounds, fischerisin A (1) and fischerisin B (2), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by interpretation of their IR, high resolution-mass spectrometry (HR-MS), 1D- and 2D-NMR data. Fischerisin A and B are the first representatives of a novel sesquiterpenoid-geranylhydroquinone hybrid, and both compounds exhibited in vitro cytotoxicity against cultured human oral epidermoid carcinoma (KB) and human breast cancer (MCF-7) cell lines with IC50 values of 9.7 and 10.2 μM, and 9.8 and 17.8 μM, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.59.511