Connecting the P300 to the diagnosis and prognosis of unconscious patients

• Published in: Neural regeneration research Vol. 10; no. 3; pp. 473 - 480
• Main Authors: Li, Ran, Song, Wei-qun, Du, Ju-bao, Huo, Su, Shan, Gui-xiang
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.03.2015; Medknow Publications & Media Pvt. Ltd; Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: acupuncture; Alzheimer′s disease; Analysis; apoptosis; apparent diffusion coefficient; astrocytes; auranofin; average combined score; blood-nerve barrier; bone marrow mesenchymal stem cells; brain injury; Brain research; caspase-3; cell transplantation; cerebral hemorrhage; cerebral ischemia; Chinese herbal formula; CHOP; cisplatin; cochlea; cognitive neuroscience; Coma; Consciousness; DAPT; dentate gyrus; dextromethorphan; differentiation; diffusion tensor imaging; disorders of consciousness; electroacupuncture therapy; electrophysiology; endoplasmic reticulum stress; evaluation; Evans blue tracer; event-related potential; fiber tractography; fractional anisotropy; gene therapy; glaucoma; GRP78; Hes1; hippocampus; hypothermia; immunohistochemistry; inflammation; intraocular pressure; JNK3; laser photocoagulation; lipid peroxidation; lumbar puncture; magnetic guidance; magnetic resonance image; magnetic resonance imaging; malondialdehyde; Mental disorders; microglia; minimally conscious state; motor learning; nanocarrier; nerve growth factor receptor; nerve regeneration; neural degeneration; neural regeneration; neural stem cells; neurodegeneration; neuroinflammation; neurons; neuroprotection; notch signaling pathway; Notch1; NSFC grant; NSFC grants; nutritional state; ocular hypertension; ongluo Jiunao injection; ototoxicity; P300; Paradigms; paraquat; peripheral nerve injury; poisoning; polyethyleneimine-polyethylene glycol; PP2; primary motor area; prognosis; proliferation; rats; reactive oxygen species; real-time quantitative PCR; regeneration; retinal ganglion cell; rosiglitazone; sciatic nerve; SMAD3; spinal cord; spinal cord injury; spinal cord transection; spiral ganglion cells; Src kinase; superparamagnetic iron oxide; survival curve; tamoxifen; task difficulty; Tneurotrophic factor; transcranial direct current stimulation; transforming growth factor β1; trauma; type 1 diabetes; ulinastatin; Unconscious (Psychology); unconsciousness; visuomotor coordination; western blot assay; X-linked inhibitor of apoptosis protein; Xuesai Tong; 事件相关电位; 昏迷; 第二范式; 等待时间; 诊断; 连接; 预后; China; Beijing China; consciousness; P300; unconsciousness; event-related potential; prognosis; nutritional state; minimally conscious state; disorders of consciousness; evaluation; brain injury; neural regeneration; electrophysiology; NSFC grants; nerve regeneration; cognitive neuroscience
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.153699

The residual consciousness of unconscious patients can be detected by studying the P300, a wave among event-related potentials. Previous studies have applied tones, the subject＇s name and other names as stimuli. However, the results were not satisfactory. In this study, we changed the constituent order of subjects＇ two-character names to create derived names. The subject＇s derived names, together with tones and their own names, were used as auditory stimuli in event-related potential experiments. Healthy controls and unconscious patients were included in this study and made to listen to these auditory stimuli. In the two paradigms, a sine tone followed by the subject＇s own name and the subject＇s derived name followed by the subject＇s own name were used as standard and deviant stimuli, respectively. The results showed that all healthy controls had the P300 using both paradigms, and that the P300 in the second paradigm had a longer latency and two peaks. All minimally conscious state patients had the P300 in the first paradigm and the majority of them had the P300 in the second paradigm. Most vegetative state patients had no P300. Patients who showed the P300 in the two paradigms had more residual consciousness, and patients with the two-peak P300 had a higher probability of awakening within a short time. Our experimental findings suggest that the P300 event-related potential could reflect the conscious state of unconscious patients.