Levofloxacin-resistant haemophilus influenzae, Taiwan, 2004-2010

• Published in: Emerging infectious diseases Vol. 20; no. 8; pp. 1386 - 1390
• Main Authors: Kuo, Shu-Chen, Chen, Pei-Chen, Shiau, Yih-Ru, Wang, Hui-Ying, Lai, 1st, Jui-Fen, Huang, Wen, Lauderdale, Tsai-Ling Yang
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.08.2014; Centers for Disease Control and Prevention
• Subjects: Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacology; Cluster Analysis; Cross Infection; Dispatch; Drug resistance; Drug Resistance, Bacterial; Drug therapy; Electrophoresis, Gel, Pulsed-Field; fluoroquinolone resistance; GyrA; Haemophilus Infections - epidemiology; Haemophilus Infections - history; Haemophilus Infections - microbiology; Haemophilus influenzae; Haemophilus influenzae - classification; Haemophilus influenzae - drug effects; Haemophilus influenzae - genetics; Haemophilus influenzae - isolation & purification; Health aspects; Hemophilus influenzae; History, 21st Century; Humans; Levofloxacin; Levofloxacin - pharmacology; Middle Aged; Multilocus Sequence Typing; ParC; Patient outcomes; Public Health Surveillance; respiratory infections; Taiwan; Taiwan - epidemiology; Taiwan; GyrA; bacteria; antimicrobial resistance; levofloxacin; ParC; Taiwan; fluoroquinolone resistance; Haemophilus influenzae; respiratory infections
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2008.140341

Levofloxacin resistance in Haemophilus influenzae has increased significantly in Taiwan, from 2.0% in 2004 to 24.3% in 2010 (p<0.001). Clinical and molecular investigations of 182 levofloxacin-resistant isolates revealed that the increase was mainly the result of the spread of several clones in the elderly population in different regions.