Early recurrence of proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal allograft

• Published in: Saudi journal of kidney diseases and transplantation Vol. 27; no. 2; pp. 381 - 385
• Main Authors: Iyer, Rajaram, Sakhuja, Vinay, Tiwari, Rohit, Kumar, Ashwani, Joshi, Kusum, Minz, Mukut, Rayat, CS
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01.03.2016; Wolters Kluwer - Medknow Publications; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Allografts; Antibodies, Monoclonal - analysis; Biomarkers - analysis; Biopsy; Care and treatment; Cell proliferation; Complications; Diagnosis; Fluorescent Antibody Technique; Glomerulonephritis; Glomerulonephritis, Membranoproliferative - diagnosis; Glomerulonephritis, Membranoproliferative - immunology; Glomerulonephritis, Membranoproliferative - surgery; Health aspects; Hematopoietic Stem Cell Transplantation; Humans; Immunoglobulin G; Immunoglobulin kappa-Chains - analysis; Immunological aspects; Kidney - immunology; Kidney - pathology; Kidney transplantation; Kidney Transplantation - adverse effects; Kidneys; Male; Middle Aged; Multiple myeloma; Multiple Myeloma - diagnosis; Multiple Myeloma - immunology; Multiple Myeloma - surgery; Patient outcomes; Recurrence; Time Factors; Transplantation; Treatment Outcome; الأجسام المضادة; التشخيص التفريقي; التهاب كبيبات الكلى; الكلى; المضاعفات; دراسات الحالة; زرع الأعضاء; Saudi Arabia
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.178568

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a clinico-pathologic entity, the recurrence of which in the renal allograft has only recently been described. A 55-year-old male presented with rapid deterioration of renal function. Light microscopy showed membranoproliferative glomerulonephritis with kappa light chain restriction and only one sub-class of IgG. He subsequently underwent renal transplant. Two months later, he developed acute graft dysfunction. Renal biopsy showed a recurrence of the disease. Work up for multiple myeloma was positive. Membranoproliferative pattern of injury in the posttransplant setting has a wide range of differential diagnosis, PGNMID being one of them.