Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs

• Published in: Journal of Veterinary Medical Science Vol. 83; no. 5; pp. 837 - 840
• Main Authors: YABUKI, Akira, FURUSAWA, Yu, MIYOSHI, Noriaki, TANIGUCHI, Kazuyuki, YAMATO, Osamu
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2021; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Angiotensin; chronic kidney disease; Dogs; dysplastic kidney; immunohistochemistry; Immunoreactivity; Kidneys; neuronal nitric oxide synthase; Nitric oxide; Nitric-oxide synthase; Pathology; Renal failure; Renin; dysplastic kidney; neuronal nitric oxide synthase; chronic kidney disease; immunohistochemistry; renin
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.21-0074

Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems. The present study investigated the expression of renin and neuronal nitric oxide synthase in the dysplastic kidneys of three young dogs. Renin-immunoreactivity, which occurs in the juxtaglomerular and tubular cells of dysplastic kidneys, did not differ from that in the normal kidneys of young dogs. Macula densa cells in the normal kidneys showed neuronal nitric oxide synthase -immunoreactivity, but those in the dysplastic kidneys showed no apparent signals. This observation may be correlated with the pathological mechanisms of renal failure in young dogs.