Serum or Bile Affects the In Vitro Azole Susceptibilities of Candida spp

Drug susceptibility tests were performed with a series of Candida spp. in media supplemented with serum or bile. The azole susceptibilities of several medically important Candida spp., including C. albicans but not C. parapsilosis, were significantly reduced in supplemented media. These findings hav...

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Bibliographic Details
Published inJapanese Journal of Infectious Diseases Vol. 62; no. 4; pp. 306 - 308
Main Authors Nagi, Minoru, Tanabe, Koichi, Takano, Yukie, Kikuchi, Ken, Miyazaki, Yoshitsugu, Niimi, Masakazu
Format Journal Article
LanguageEnglish
Published Japan National Institute of Infectious Diseases 29.07.2009
Subjects
Animals
Antifungal Agents - pharmacology
Azoles - pharmacology
Bile - metabolism
Candida
Candida albicans - drug effects
Drug Antagonism
Humans
Microbial Sensitivity Tests
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Summary:Drug susceptibility tests were performed with a series of Candida spp. in media supplemented with serum or bile. The azole susceptibilities of several medically important Candida spp., including C. albicans but not C. parapsilosis, were significantly reduced in supplemented media. These findings have important implications for the mechanisms of acquired azole resistance in pathogenic fungi.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1344-6304
1884-2836
DOI:10.7883/yoken.JJID.2009.306