Evaluation of commercially available anti-dengue virus immunoglobulin M tests

• Published in: Emerging infectious diseases Vol. 15; no. 3; pp. 436 - 440
• Main Authors: Hunsperger, Elizabeth A, Yoksan, Sutee, Buchy, Philippe, Nguyen, Vinh Chau, Sekaran, Shamala D, Enria, Delia A, Pelegrino, Jose L, Vázquez, Susana, Artsob, Harvey, Drebot, Michael, Gubler, Duane J, Halstead, Scott B, Guzmán, María G, Margolis, Harold S, Nathanson, Carl-Michael, Rizzo Lic, Nidia R, Bessoff, Kovi E, Kliks, Srisakul, Peeling, Rosanna W
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.03.2009; Centers for Disease Control and Prevention
• Subjects: Antibodies, Viral - blood; Dengue - diagnosis; Dengue - virology; Dengue fever; Dengue Virus - immunology; Diagnosis; diagnostic test; Disease transmission; Dispatch; ELISA; Enzyme-Linked Immunosorbent Assay; False Positive Reactions; Health aspects; Humans; Immunoglobulin M; Immunoglobulin M - blood; Infection; Public health; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Thailand
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid1503.080923

Anti-dengue virus immunoglobulin M kits were evaluated. Test sensitivities were 21%-99% and specificities were 77%-98% compared with reference ELISAs. False-positive results were found for patients with malaria or past dengue infections. Three ELISAs showing strong agreement with reference ELISAs will be included in the World Health Organization Bulk Procurement Scheme.