Facing Cell Autophagy in Gastric Cancer - What Do We Know so Far?

Autophagy is a process by which misfolded proteins and damaged organelles in the lysosomes of tumor cells were degraded reusing decomposed substances and avoiding accumulation of large amounts of harmful substances. Here, the role of autophagy in the development of malignant transformation of gastri...

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Bibliographic Details
Published inInternational journal of general medicine Vol. 14; pp. 1647 - 1659
Main Authors Xiu, Ting, Guo, Qie, Jing, Fan-Bo
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2021
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects
Apoptosis
Autophagy
autophagy;gastric cancer;autophagy-related genes;lysosomes;targeted therapy
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Gastric cancer
Gene expression
Genotype & phenotype
Health aspects
Kinases
Medical prognosis
Metastasis
Mortality
Prognosis
Proteins
Review
Stomach cancer
Tumors
targeted therapy
lysosomes
autophagy
gastric cancer
autophagy-related genes
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Summary:Autophagy is a process by which misfolded proteins and damaged organelles in the lysosomes of tumor cells were degraded reusing decomposed substances and avoiding accumulation of large amounts of harmful substances. Here, the role of autophagy in the development of malignant transformation of gastric tumors, and the underlying mechanisms involved in autophagy formation, and the application of targeted autophagy in the treatment of gastric cancer were summarized.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S298705