循环微小RNA诊断心肌病变的研究进展

微小RNA（microRNA,miRNA）是一组长度为19-25个核苷酸的非编码RNA,在细胞增殖、分化、发育及死亡过程中发挥重要作用。在血浆中稳定存在并可检测的miRNA称为循环miRNA。近年来研究表明循环miRNA可作为诊断心肌病变的新型潜在生物标志物。本文就循环miRNA早期诊断心力衰竭、心肌梗死及药物性心脏毒性等心肌病变的临床与实验研究进展作一综述。...

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Bibliographic Details
Published in复旦学报（医学版） Vol. 44; no. 1; pp. 110 - 116
Main Author 张楚婕 程蕾蕾
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院心脏超声诊断科 上海200032 2017
上海市心血管病研究所 上海200032
上海市影像医学研究所 上海200032
Subjects
循环miRNA
心力衰竭
心房颤动
急性心肌梗死
生物标志物
肥厚型心肌病
药物性心脏毒性
heart failure
急性心肌梗死
循环miRNA
生物标志物
心房颤动
biomarker
atrial fibrillation
drug-induced cardiotoxicity
药物性心脏毒性
hypertrophic cardiomyopathy
心力衰竭
肥厚型心肌病
acute myocardial infarction
circulation miRNA
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ISSN1672-8467
DOI10.3969/j.issn.1672-8467.2017.01.019

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Summary:微小RNA（microRNA,miRNA）是一组长度为19-25个核苷酸的非编码RNA,在细胞增殖、分化、发育及死亡过程中发挥重要作用。在血浆中稳定存在并可检测的miRNA称为循环miRNA。近年来研究表明循环miRNA可作为诊断心肌病变的新型潜在生物标志物。本文就循环miRNA早期诊断心力衰竭、心肌梗死及药物性心脏毒性等心肌病变的临床与实验研究进展作一综述。
Bibliography:ZHANG Chu-jie1,2,3, CHENG Lei-lei1,2,3（1Department of Echoeardiography , Zhongshan Hospital, Fudan University, Shanghai 200032, China 2 Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China ; 3Shanghai Institute of Medical Imaging, Shanghai 200032, China）
circulation miRNA; biomarker; acute myocardial infarction; heart failure; hypertrophic cardiomyopathy; atrial fibrillation; drug-induced cardiotoxicity
31-1885/R
MicroRNA（ miRNA） is a class of 19-25-nucleotide non-coding RNAs that plays an important role in cellular proliferation,differentiation,development as well as cell death. The miRNA that can be detected in the plasma is known as circulating miRNA,and it can exist stable in the circulation of the blood.Recently,circulating miRNA has been increasingly suggested as novel potential biomarkers of a series of myocardial lesions. This review article summarized the progress of clinical and experimental studies of circulating miRNA as early diagnosis index for cardiopathologic conditions,including
ISSN:1672-8467
DOI:10.3969/j.issn.1672-8467.2017.01.019