Disseminated histiocytic sarcoma in a degu (Octodon degus)

• Published in: Journal of Veterinary Medical Science Vol. 86; no. 5; pp. 529 - 532
• Main Authors: IKEDA, Mitsuhiro, KONDO, Hirotaka, HAMADA, Fuyu, YAMASHITA, Tomoyuki, SHIBUYA, Hisashi
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2024; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; Anorexia; degu; Effusion; Fatal Outcome; Giant cells; histiocytic sarcoma; Histiocytic Sarcoma - pathology; Histiocytic Sarcoma - veterinary; Histocompatibility antigen HLA; immunohistochemistry; Male; Mesentery; Necropsy; neoplasm; Octodon; Octodon degus; Sarcoma; Splenomegaly; Thorax; Wildlife Science; degu; histiocytic sarcoma; Octodon degus; neoplasm; immunohistochemistry
• ISSN: 0916-7250; 1347-7439; 1347-7439
• DOI: 10.1292/jvms.24-0081

A 7-year-and-8-month-old, male degu (Octodon degus) with anorexia, depression, and labored breathing was found to have a thoracic effusion and enlargement of the right testis on radiographic examination. Despite treatment, the animal died. At necropsy, hepatomegaly, splenomegaly, and multifocal nodules on the intestinal serosa and mesentery were observed. Histologically, the foci were densely cellular invasive neoplasms composed of sheets of round to polygonal cells, with occasional multinucleated giant cells. Immunohistochemically, the neoplastic cells were immunopositive for ionized calcium-binding adapter molecule 1, human leukocyte antigen-DR, and CD204. These findings were consistent with disseminated histiocytic sarcoma.