Negative correlation between CSF zinc level and anxiety in male Chinese subjects
Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc level and anxiety in a group of male Chinese subjects. Results demonstrated that zinc levels had no considerable interindividual variations,...
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| Published in | Psychiatry research Vol. 246; pp. 841 - 843 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
30.12.2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0165-1781 1872-7123 |
| DOI | 10.1016/j.psychres.2016.10.067 |
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| Abstract | Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc level and anxiety in a group of male Chinese subjects. Results demonstrated that zinc levels had no considerable interindividual variations, ranging from 8.37 to 16.83µm. Correlation analyses revealed that CSF Zinc levels were positively correlated with education years (r=0.225, p=0.024) and negatively correlated with SAS scores (r=−0.287, p=0.004), but not associated with age or BMI. In conclusion, this present study suggests that CSF zinc level is associated with anxiety.
•CSF zinc levels showed no considerable interindividual variations, ranging from 8.37 to 16.83 μM.•CSF Zinc level is positively correlated with education years and negatively with SAS scores in Chinese male subjects.•CSF Zinc level is not associated with age or BMI.•The present study suggests that CSF zinc level is associated with anxiety. |
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| AbstractList | Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc level and anxiety in a group of male Chinese subjects. Results demonstrated that zinc levels had no considerable interindividual variations, ranging from 8.37 to 16.83µm. Correlation analyses revealed that CSF Zinc levels were positively correlated with education years (r=0.225, p=0.024) and negatively correlated with SAS scores (r=−0.287, p=0.004), but not associated with age or BMI. In conclusion, this present study suggests that CSF zinc level is associated with anxiety.
•CSF zinc levels showed no considerable interindividual variations, ranging from 8.37 to 16.83 μM.•CSF Zinc level is positively correlated with education years and negatively with SAS scores in Chinese male subjects.•CSF Zinc level is not associated with age or BMI.•The present study suggests that CSF zinc level is associated with anxiety. Abstract Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc level and anxiety in a group of male Chinese subjects. Results demonstrated that zinc levels had no considerable interindividual variations, ranging from 8.37 to 16.83 µm. Correlation analyses revealed that CSF Zinc levels were positively correlated with education years ( r =0.225, p =0.024) and negatively correlated with SAS scores ( r =−0.287, p =0.004), but not associated with age or BMI. In conclusion, this present study suggests that CSF zinc level is associated with anxiety. Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc level and anxiety in a group of male Chinese subjects. Results demonstrated that zinc levels had no considerable interindividual variations, ranging from 8.37 to 16.83µm. Correlation analyses revealed that CSF Zinc levels were positively correlated with education years (r=0.225, p=0.024) and negatively correlated with SAS scores (r=-0.287, p=0.004), but not associated with age or BMI. In conclusion, this present study suggests that CSF zinc level is associated with anxiety. |
| Author | Wang, Jian Liu, Yanlong Yu, Dongsheng Song, Na Kang, Yimin Cao, Zhiyong Yang, Xiaoyu Wang, Fan |
| Author_xml | – sequence: 1 givenname: Na surname: Song fullname: Song, Na organization: Department of Molecular Biology and Biochemistry, Xinxiang Medical University, Xinxiang 453003, China – sequence: 2 givenname: Dongsheng surname: Yu fullname: Yu, Dongsheng organization: Inner Mongolia Region Mental Health Center, Huhhot 010110, China – sequence: 3 givenname: Yimin surname: Kang fullname: Kang, Yimin organization: Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China – sequence: 4 givenname: Zhiyong surname: Cao fullname: Cao, Zhiyong organization: The PLA Psychiatry Center, The 102nd Hospitial of PLA, Changzhou 213003, China – sequence: 5 givenname: Xiaoyu surname: Yang fullname: Yang, Xiaoyu organization: Beijing Jishuitan Hospital, Beijing 100035, China – sequence: 6 givenname: Jian surname: Wang fullname: Wang, Jian organization: Psychology and Sleep Department of Guang׳an Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China – sequence: 7 givenname: Yanlong surname: Liu fullname: Liu, Yanlong email: benjaminlyl@wmu.edu.cn organization: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China – sequence: 8 givenname: Fan surname: Wang fullname: Wang, Fan email: FanWang@bjmu.edu.cn organization: Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27825785$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_aimed_2021_04_002 crossref_primary_10_1016_j_brainresbull_2018_12_015 crossref_primary_10_1016_j_envres_2021_112049 crossref_primary_10_1080_14659891_2019_1664656 crossref_primary_10_3390_dietetics2010008 |
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| Snippet | Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc... Abstract Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid... |
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| SubjectTerms | Adult Anxiety - cerebrospinal fluid Anxiety - diagnosis Anxiety - psychology Asian Continental Ancestry Group - psychology Biomarkers - cerebrospinal fluid CSF Educational Status Humans Male Psychiatry SAS Young Adult Zinc Zinc - cerebrospinal fluid |
| Title | Negative correlation between CSF zinc level and anxiety in male Chinese subjects |
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