Negative correlation between CSF zinc level and anxiety in male Chinese subjects

• Published in: Psychiatry research Vol. 246; pp. 841 - 843
• Main Authors: Song, Na, Yu, Dongsheng, Kang, Yimin, Cao, Zhiyong, Yang, Xiaoyu, Wang, Jian, Liu, Yanlong, Wang, Fan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 30.12.2016
• Subjects: Adult; Anxiety - cerebrospinal fluid; Anxiety - diagnosis; Anxiety - psychology; Asian Continental Ancestry Group - psychology; Biomarkers - cerebrospinal fluid; CSF; Educational Status; Humans; Male; Psychiatry; SAS; Young Adult; Zinc; Zinc - cerebrospinal fluid; SAS; Zinc; CSF
• ISSN: 0165-1781; 1872-7123
• DOI: 10.1016/j.psychres.2016.10.067

Zinc is crucial for brain development and psychiatric regulation. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) zinc level and anxiety in a group of male Chinese subjects. Results demonstrated that zinc levels had no considerable interindividual variations, ranging from 8.37 to 16.83µm. Correlation analyses revealed that CSF Zinc levels were positively correlated with education years (r=0.225, p=0.024) and negatively correlated with SAS scores (r=−0.287, p=0.004), but not associated with age or BMI. In conclusion, this present study suggests that CSF zinc level is associated with anxiety. •CSF zinc levels showed no considerable interindividual variations, ranging from 8.37 to 16.83 μM.•CSF Zinc level is positively correlated with education years and negatively with SAS scores in Chinese male subjects.•CSF Zinc level is not associated with age or BMI.•The present study suggests that CSF zinc level is associated with anxiety.