Multisystem Inflammatory Syndrome in Adult after First Dose of mRNA Vaccine

• Published in: Emerging infectious diseases Vol. 28; no. 4; pp. 870 - 872
• Main Authors: Miyazato, Yusuke, Yamamoto, Kei, Yamada, Gen, Kubota, Shuji, Ishikane, Masahiro, Sugiyama, Masaya, Ueno, Mikako, Matsunaga, Akihiro, Miyoshi-Akiyama, Tohru, Ishizaka, Yukihito, Ohmagari, Norio
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.04.2022; Centers for Disease Control and Prevention
• Subjects: Adult; coronavirus disease; Coronaviruses; COVID-19; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - adverse effects; Disease control; Disease prevention; Disease transmission; Drug dosages; Dyspnea; Edema; Fever; Humans; Immunization; Infections; Infectious diseases; Male; Medical laboratories; Medical research; Medicine; mRNA Vaccines; Multisystem Inflammatory Syndrome in Adult after First Dose of mRNA Vaccine; Multisystem inflammatory syndrome in children; Myocarditis; Patients; R&D; Research & development; Research Letter; respiratory failure; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Steroids; vaccination; Vaccines, Synthetic; Ventilation; Japan; United States > US; anti-nucleocapsid antibody; Japan; COVID-19; SARS-CoV-2; cytokine profile; myocardial injury; MIS-A; severe acute respiratory syndrome coronavirus 2; respiratory failure; anti-spike antibody; coronavirus disease; multisystem inflammatory syndrome; hyperinflammatory state; vaccination
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid2804.212585

A 32-year-old man in Japan experienced respiratory failure after receiving the first dose of coronavirus disease (COVID-19) vaccine. He was treated with noninvasive ventilation and corticosteroids. Serologic test results suggested previous COVID-19; therefore, he received a diagnosis of multisystem inflammatory syndrome. COVID-19 vaccination could be a trigger for this condition.