Salience and Default Mode Network Coupling Predicts Cognition in Aging and Parkinson’s Disease

• Published in: Journal of the International Neuropsychological Society Vol. 22; no. 2; pp. 205 - 215
• Main Authors: Putcha, Deepti, Ross, Robert S., Cronin-Golomb, Alice, Janes, Amy C., Stern, Chantal E.
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.02.2016
• Subjects: Age; Aged; Aging - pathology; Brain Mapping; Case-Control Studies; Cognition & reasoning; Cognition Disorders - diagnostic imaging; Cognition Disorders - etiology; Cognitive ability; Dementia; Education; Executive Function - physiology; Female; Humans; Male; Memory - physiology; Middle Aged; Neural Pathways - diagnostic imaging; Neural Pathways - physiopathology; Neuropsychological Tests; Parkinson Disease - complications; Parkinson's disease; Psychomotor Disorders - diagnostic imaging; Psychomotor Disorders - etiology; Verbal Learning; Intrinsic connectivity networks; Functional magnetic resonance imaging; Default mode network; Salience network; Neurodegeneration; Cognitive impairment
• ISSN: 1355-6177; 1469-7661
• DOI: 10.1017/S1355617715000892

Objectives: Cognitive impairment is common in Parkinson’s disease (PD). Three neurocognitive networks support efficient cognition: the salience network, the default mode network, and the central executive network. The salience network is thought to switch between activating and deactivating the default mode and central executive networks. Anti-correlated interactions between the salience and default mode networks in particular are necessary for efficient cognition. Our previous work demonstrated altered functional coupling between the neurocognitive networks in non-demented individuals with PD compared to age-matched control participants. Here, we aim to identify associations between cognition and functional coupling between these neurocognitive networks in the same group of participants. Methods: We investigated the extent to which intrinsic functional coupling among these neurocognitive networks is related to cognitive performance across three neuropsychological domains: executive functioning, psychomotor speed, and verbal memory. Twenty-four non-demented individuals with mild to moderate PD and 20 control participants were scanned at rest and evaluated on three neuropsychological domains. Results: PD participants were impaired on tests from all three domains compared to control participants. Our imaging results demonstrated that successful cognition across healthy aging and Parkinson’s disease participants was related to anti-correlated coupling between the salience and default mode networks. Individuals with poorer performance scores across groups demonstrated more positive salience network/default-mode network coupling. Conclusions: Successful cognition relies on healthy coupling between the salience and default mode networks, which may become dysfunctional in PD. These results can help inform non-pharmacological interventions (repetitive transcranial magnetic stimulation) targeting these specific networks before they become vulnerable in early stages of Parkinson’s disease. (JINS, 2016, 22, 205–215)