Maximum volume of nasal administration using a mucosal atomization device without aspiration in Japanese White rabbits

• Published in: Journal of Veterinary Medical Science Vol. 84; no. 6; pp. 792 - 798
• Main Authors: WEI, Yixian, HORI, Ai, CHEN, I-Ying, TAMOGI, Haruka, HIROKAWA, Taku, KATO, Keiko, ITAMI, Takaharu, SANO, Tadashi, YAMASHITA, Kazuto
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2022; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Administration, Intranasal - veterinary; Anesthesia; Animals; Butorphanol; Computed tomography; Contrast media; Female; Intranasal administration; Japan; Medetomidine; Mucosa; mucosal atomization device (MAD); nasal atomization volume; Nasal Cavity; Nose; Oral cavity; rabbit; Rabbits; Surgery; Trachea; Veterinary medicine; Japan; nasal atomization volume; mucosal atomization device (MAD); intranasal administration; rabbit
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.21-0648

Recently, a mucosal atomization device (MAD) has been applied in veterinary medicine. In the present study, the maximum volume of nasal atomization without aspiration using MAD was examined in eight healthy female Japanese White (JW) rabbits. Each rabbit had their head and neck examined by computed tomography before and after nasal atomization with four different doses (0.15, 0.3, 0.45, and 0.6 ml per nostril) of diluted contrast medium (1:2 mixture of iohexol and saline). This was done under general anesthesia by an intramuscular administration of alfaxalone 2.5 mg/kg, medetomidine 40 μg/kg, and butorphanol 0.4 mg/kg, with a 7-day washout period between each treatment. The diluted contrast medium was distributed in the nasal cavity, external nares, and/or oral cavity in all rabbits receiving each treatment. The intranasal distribution volumes of the contrast medium were 287 (250–333) mm3 [median (interquartile range)] for 0.15 ml, 433 (243–555) mm3 for 0.3 ml, 552 (356–797) mm3 for 0.45 ml, and 529 (356–722) mm3 for 0.6 ml of treatment. The intranasal distribution volume for 0.15 ml treatment tended to be lower than that for 0.6 ml treatment (P=0.083). The contrast medium was deposited in the trachea in one rabbit (12.5%) and four rabbits (50%) receiving treatments of 0.45 and 0.6 ml per nostril, respectively. The maximum volume of nasal atomization without aspiration into the trachea was 0.3 ml per nostril for the JW rabbits.